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. 2017 May;35(3):255-264.
doi: 10.1007/s00774-016-0757-8. Epub 2016 Apr 16.

MiR-142-5p promotes bone repair by maintaining osteoblast activity

Manli Tu  1 , Juanjuan Tang  2 , Hongbo He  3 , Peng Cheng  4 , Chao Chen  5
Affiliations

MiR-142-5p promotes bone repair by maintaining osteoblast activity

Manli Tu et al. J Bone Miner Metab. 2017 May.

Abstract

MicroRNAs play important roles in regulating bone regeneration and remodeling. However, the pathophysiological roles of microRNAs in bone repair remain unclear. Here we identify a significant upregulation of miR-142-5p correlated with active osteoblastogenesis during the bone healing process. In vitro, miR-142-5p promoted osteoblast activity and matrix mineralization by targeting the gene encoding WW-domain-containing E3 ubiquitin protein ligase 1. We also found that the expression of miR-142-5p in the callus of aged mice was lower than that in the callus of young mice and directly correlated with the age-related delay in bone healing. Furthermore, treatment with agomir-142-5p in the fracture areas stimulated osteoblast activity which repaired the bone fractures in aged mice. Thus, our study revealed that miR-142-5p plays a crucial role in healing fractures by maintaining osteoblast activity, and provided a new molecular target therapeutic strategy for bone healing.

Keywords: Bone fracture; MicroRNA; Osteoblastogenesis; Wwp1.

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