Adaptive immunity in HBV infection
- PMID: 27084039
- DOI: 10.1016/j.jhep.2016.01.026
Adaptive immunity in HBV infection
Abstract
During hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately determines HBV infection outcome. In this review, in addition to summarizing the present state of knowledge of HBV-adaptive immunity, we will highlight controversies and uncertainties concerning the HBV-specific B and T lymphocyte response, and propose future directions for research aimed at the generation of more efficient immunotherapeutic strategies.
Keywords: Antiviral immunity; B lymphocytes; Immunodominance; T cell exhaustion; T lymphocytes.
Copyright © 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Similar articles
-
Plasmacytoid dendritic cells induce efficient stimulation of antiviral immunity in the context of chronic hepatitis B virus infection.Hepatology. 2012 Nov;56(5):1706-18. doi: 10.1002/hep.25879. Epub 2012 Aug 27. Hepatology. 2012. PMID: 22707082
-
Recognition of Core- and Polymerase-derived immunogenic peptides included in novel therapeutic vaccine by T cells from Chinese chronic hepatitis B patients.J Viral Hepat. 2017 Nov;24 Suppl 1:66-74. doi: 10.1111/jvh.12791. J Viral Hepat. 2017. PMID: 29082648
-
In vitro use of autologous dendritic cells improves detection of T cell responses to hepatitis B virus (HBV) antigens.J Med Virol. 2009 Feb;81(2):332-9. doi: 10.1002/jmv.21333. J Med Virol. 2009. PMID: 19107973
-
Innate immunity and HBV persistence.Curr Opin Virol. 2021 Aug;49:13-20. doi: 10.1016/j.coviro.2021.04.003. Epub 2021 May 13. Curr Opin Virol. 2021. PMID: 33992859 Free PMC article. Review.
-
Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses.Cell Mol Immunol. 2015 May;12(3):273-82. doi: 10.1038/cmi.2014.112. Epub 2014 Nov 24. Cell Mol Immunol. 2015. PMID: 25418467 Free PMC article. Review.
Cited by
-
HBV immune tolerance of HBs-transgenic mice observed through parabiosis with WT mice.Front Immunol. 2022 Sep 20;13:993246. doi: 10.3389/fimmu.2022.993246. eCollection 2022. Front Immunol. 2022. PMID: 36203595 Free PMC article.
-
AAV Immunotoxicity: Implications in Anti-HBV Gene Therapy.Microorganisms. 2023 Dec 14;11(12):2985. doi: 10.3390/microorganisms11122985. Microorganisms. 2023. PMID: 38138129 Free PMC article. Review.
-
Harnessing CD8+ T cell dynamics in hepatitis B virus-associated liver diseases: Insights, therapies and future directions.Clin Transl Med. 2024 Jul;14(7):e1731. doi: 10.1002/ctm2.1731. Clin Transl Med. 2024. PMID: 38935536 Free PMC article. Review.
-
Inflammatory Response in the Pathogenesis and Treatment of Hepatocellular Carcinoma: A Double-Edged Weapon.Int J Mol Sci. 2024 Jun 29;25(13):7191. doi: 10.3390/ijms25137191. Int J Mol Sci. 2024. PMID: 39000296 Free PMC article. Review.
-
Genetic variations underlying Gilbert syndrome and HBV infection outcomes: a cross-sectional study.Front Genet. 2023 Nov 6;14:1265268. doi: 10.3389/fgene.2023.1265268. eCollection 2023. Front Genet. 2023. PMID: 38028601 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
