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. 2016 Apr 14;11(4):e0153843.
doi: 10.1371/journal.pone.0153843. eCollection 2016.

A Normative Model of Serum Inhibin B in Young Males

Thomas W Kelsey  1 , Amy Miles  2 , Rod T Mitchell  3 , Richard A Anderson  3 , W Hamish B Wallace  4
Affiliations

A Normative Model of Serum Inhibin B in Young Males

Thomas W Kelsey et al. PLoS One. .

Abstract

Inhibin B has been identified as a potential marker of Sertoli cell function in males. The aim of this study is to produce a normative model of serum inhibin B in males from birth to seventeen years. We used a well-defined search strategy to identify studies containing data that can contribute to a larger approximation of the healthy population. We combined data from four published studies (n = 709) and derived an internally validated model with high goodness-of-fit and normally distributed residuals. Our results show that inhibin B increases following birth to a post-natal peak of 270 pg/mL (IQR 210-335 pg/mL) and then decreases during childhood followed by a rise at around 8 years, peaking at a mean 305 pg/mL (IQR 240-445 pg/mL) at around age 17. Following this peak there is a slow decline to the standard mature adult normal range of 170 pg/mL (IQR 125-215 pg/mL). This normative model suggests that 35% of the variation in Inhibin B levels in young males is due to age alone, provides an age-specific reference range for inhibin B in the young healthy male population, and will be a powerful tool in evaluating the potential of inhibin B as a marker of Sertoli cell function in pre-pubertal boys.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Root transformed Inhibin B levels.
The red line is the model that best fits the 709 data points, which are indicated by blue squares. The model has r2 = 0.35, indicating that 35% of the variation in inhibin B levels in young males is due to age alone. The green lines represent the upper and lower 95% confidence limits for the predicted mean and the orange lines the upper and lower 95% prediction limits.
Fig 2
Fig 2. Model residuals.
The residuals are the variations in root-adjusted observed values from the root-adjusted age-related mean value predicted by the model. The residuals have 97% goodness of fit to an ideal Gaussian curve.
Fig 3
Fig 3. The Normative Model.
Inhibin B levels in human males from birth to age 17 years expressed as standard centiles.
See this image and copyright information in PMC

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References

    1. Anderson RA, Sharpe RM. Regulation of inhibin production in the human male and its clinical applications. International journal of andrology. 2000;23(3):136–44. - PubMed
    1. Rey RA, Grinspon RP, Gottlieb S, Pasqualini T, Knoblovits P, Aszpis S, et al. Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach. Andrology. 2013;1(1):3–16. 10.1111/j.2047-2927.2012.00008.x - DOI - PubMed
    1. Griswold MD. The central role of Sertoli cells in spermatogenesis. Semin Cell Dev Biol. 1998;9(4):411–6. 10.1006/scdb.1998.0203 - DOI - PubMed
    1. Andersson AM, Juul A, Petersen JH, Muller J, Groome NP, Skakkebaek NE. Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels. The Journal of clinical endocrinology and metabolism. 1997;82(12):3976–81. 10.1210/jcem.82.12.4449 - DOI - PubMed
    1. Barbotin AL, Ballot C, Sigala J, Ramdane N, Duhamel A, Marcelli F, et al. The serum inhibin B concentration and reference ranges in normozoospermia. European journal of endocrinology / European Federation of Endocrine Societies. 2015;172(6):669–76. 10.1530/EJE-14-0932 - DOI - PubMed

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