doi: 10.1073/pnas.74.10.4392.
Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA
- PMID: 270682
- PMCID: PMC431948
- DOI: 10.1073/pnas.74.10.4392
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Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA
Proc Natl Acad Sci U S A.
1977 Oct.
Abstract
Separated strands of adenovirus DNA were annealed with early cytoplasmic RNA and visualized in the electron microscope. DNA-RNA duplex regions within the DNA filaments could be recognized by their heavy contour. This contour was often interrupted at distinct locations by loops of displaced, single-stranded DNA. Loops have been observed and mapped in all four early regions of the genome. The structures appear to signal hitherto unknown mechanisms of eukaryotic gene expression.
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