Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients

. 2016 Jan;45(1):63-9.

Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients

Payam Farahbakhsh-Farsi¹, Abolghassem Djazayery², Mohammad Reza Eshraghian³, Fariba Koohdani¹, Mahnaz Zarei¹, Mohammad Hassan Javanbakht¹, Hoda Derakhshanian¹, Mahmoud Djalali¹

Affiliations

¹ Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
² Dept. of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
³ Dept. of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 27057523
PMCID: PMC4822396

Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients

Payam Farahbakhsh-Farsi et al. Iran J Public Health. 2016 Jan.

. 2016 Jan;45(1):63-9.

Authors

Payam Farahbakhsh-Farsi¹, Abolghassem Djazayery², Mohammad Reza Eshraghian³, Fariba Koohdani¹, Mahnaz Zarei¹, Mohammad Hassan Javanbakht¹, Hoda Derakhshanian¹, Mahmoud Djalali¹

Affiliations

¹ Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
² Dept. of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
³ Dept. of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 27057523
PMCID: PMC4822396

Abstract

Background: Serum levels of lipocalin 2 (LCN 2) and retinol-binding protein-4 (RBP 4), increase in type 2 diabetes mellitus (T2DM). We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients.

Methods: Forty-five type 2 diabetic patients from Iranian Diabetic Association in Tehran, Iran in 2013 were randomly recruited into two groups: one group received 4 g/d omega-3 for 10 wk; and the control group received placebo. Blood samples, food intake records, anthropometric measurements were obtained from all participants at the beginning and end of the study.

Results: Fasting RBP 4 plasma levels significantly changed after 10 wk supplementation (P = 0.01). The LCN 2 concentrations decreased in omega-3 group, but the changes were not statistically significant. Omega-3 supplementation had no noticeable effect on anthropometric factors.

Conclusions: These findings provide a rationale for omega-3 supplements aimed at lowering serum RBP 4 levels in T2DM.

Keywords: Diabetes mellitus; Lipocalin; Omega-3 fatty acid; Retinol-binding protein.

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References

1. Kehrer JP. (2010). Lipocalin-2: pro- or anti-apoptotic? Cell Biol Toxicol, 26: 83–9. - PubMed
1. Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y. (2005). Lipocalin 2 functions as a negative regulator of red blood cell production in an autocrine fashion. FASEB J, 19: 1881–3. - PubMed
1. Stejskal D, Karpisek M, Humenanska V, Hanulova Z, Stejskal P, Kusnierova P, Petzel M. (2008). Lipocalin-2: development, analytical characterization, and clinical testing of a new ELISA. Horm Metab Res, 40: 381–5. - PubMed
1. Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. (2007). The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes, 56: 2533–40. - PubMed
1. Tan BK, Adya R, Shan X, Syed F, Lewandowski KC, O'Hare JP, Randeva HS. (2009). Ex vivo and in vivo regulation of lipocalin-2, a novel adipokine, by insulin. Diabetes Care, 32: 129–31. - PMC - PubMed

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[1] Kehrer JP. (2010). Lipocalin-2: pro- or anti-apoptotic? Cell Biol Toxicol, 26: 83–9. - PubMed

[2] Kehrer JP. (2010). Lipocalin-2: pro- or anti-apoptotic? Cell Biol Toxicol, 26: 83–9. - PubMed

[3] Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y. (2005). Lipocalin 2 functions as a negative regulator of red blood cell production in an autocrine fashion. FASEB J, 19: 1881–3. - PubMed

[4] Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y. (2005). Lipocalin 2 functions as a negative regulator of red blood cell production in an autocrine fashion. FASEB J, 19: 1881–3. - PubMed

[5] Stejskal D, Karpisek M, Humenanska V, Hanulova Z, Stejskal P, Kusnierova P, Petzel M. (2008). Lipocalin-2: development, analytical characterization, and clinical testing of a new ELISA. Horm Metab Res, 40: 381–5. - PubMed

[6] Stejskal D, Karpisek M, Humenanska V, Hanulova Z, Stejskal P, Kusnierova P, Petzel M. (2008). Lipocalin-2: development, analytical characterization, and clinical testing of a new ELISA. Horm Metab Res, 40: 381–5. - PubMed

[7] Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. (2007). The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes, 56: 2533–40. - PubMed

[8] Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. (2007). The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes, 56: 2533–40. - PubMed

[9] Tan BK, Adya R, Shan X, Syed F, Lewandowski KC, O'Hare JP, Randeva HS. (2009). Ex vivo and in vivo regulation of lipocalin-2, a novel adipokine, by insulin. Diabetes Care, 32: 129–31. - PMC - PubMed

[10] Tan BK, Adya R, Shan X, Syed F, Lewandowski KC, O'Hare JP, Randeva HS. (2009). Ex vivo and in vivo regulation of lipocalin-2, a novel adipokine, by insulin. Diabetes Care, 32: 129–31. - PMC - PubMed

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Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients

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Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients

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