Review
doi: 10.1016/j.coph.2016.03.002.
Epub 2016 Apr 2.
Alterations of calcium homeostasis in cancer cells
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- PMID: 27043073
- DOI: 10.1016/j.coph.2016.03.002
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Review
Alterations of calcium homeostasis in cancer cells
Curr Opin Pharmacol.
2016 Aug.
Abstract
Typical hallmarks of cancer include programmed cell death evasion, uncontrolled cell growth, invasion, and metastasis. Changes in intracellular Ca(2+) levels can modulate signaling pathways that control a broad range of cellular events, including those important to tumorigenesis and cancer progression. Here we discuss how known molecular mediators of cellular Ca(2+) homeostasis impact tumor dynamics and how deregulation of major oncogenes and tumor suppressors is tightly associated with Ca(2+) signaling.
Copyright © 2016 Elsevier Ltd. All rights reserved.
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