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Case Reports
. 2016 Apr;7(Suppl 1):S88-95.
doi: 10.3978/j.issn.2078-6891.2015.021.

Coexistence of intestinal Kaposi sarcoma and plasmablastic lymphoma in an HIV/AIDS patient: case report and review of the literature

Bing Wang  1 , Bingbing Song  1 , Cyrus Oster  1 , Jeffery Cao  1 , Anwar Raza  1 , Jun Wang  1
Affiliations
Case Reports

Coexistence of intestinal Kaposi sarcoma and plasmablastic lymphoma in an HIV/AIDS patient: case report and review of the literature

Bing Wang et al. J Gastrointest Oncol. 2016 Apr.

Abstract

Human immunodeficiency virus (HIV) infection or acquired immunodeficiency disease (AIDS) is associated with increased risk for various malignancies including Kaposi sarcoma (KS) and lymphoma. We report a rare case of coexistence of KS and plasmablastic lymphoma (PBL) in the gastrointestinal (GI) tract in a HIV/AIDS patient. A brief review of literature is also presented.

Keywords: Human immunodeficiency virus (HIV); Kaposi sarcoma (KS); acquired immunodeficiency disease (AIDS); intestinal neoplasms; plasmablastic lymphoma (PBL).

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Esophageal biopsies showing esophagitis with herpetic viral inclusions (A) and cytomegaloviral inclusions (B) (HE stain: A, ×200; B, ×400).
Figure 2
Figure 2
Duodenal biopsies showing typical KS features: spindle cell lesions with extravasated red blood cells that expand lamina propria (A: low power view; B: high power view (HE stain: A, ×40; B, ×400).
Figure 3
Figure 3
Descending colon biopsies (A: top, HE stain, ×100; bottom, immunoperoxidase stain, ×400. B: top, HE stain, ×400; bottom, immunoperoxidase stain, ×100). The low power view (A) revealed two different types of lesions. Foci of atypical large cell infiltration were found near the mucosa surface, and those large cells often appear plasmacytoid with abundant cytoplasm, eccentric nuclei and variably prominent nucleoli (B), which was CD45 positive. Underneath is the lesion of KS, CD34 staining showing the haphazard vascular network of Kaposi sarcoma in the lamina propria. KS, Kaposi sarcoma.
Figure 4
Figure 4
PBL. In H&E stain, a population of large cells with plasmacytoid appearance. PBL cells are CD20 negative, CD138 and MUM1 positive, and show a high Ki67 expression. PBL exhibits positive EBER expression by in situ hybridization (original magnification for EBER is ×200 and the rest are all ×400). PBL, plasmablastic lymphoma.
See this image and copyright information in PMC

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