Essentials of Glycobiology [Internet]
- PMID: 27010055
- Bookshelf ID: NBK310274
Essentials of Glycobiology [Internet]
Excerpt
Defined in the broadest sense, Glycobiology is the study of the structure, biosynthesis, biology, and evolution of saccharides (sugar chains or glycans) that are widely distributed in nature in all living life forms. Glycobiology is now one of the more rapidly growing fields in the natural sciences, with broad relevance to many areas of basic research, biomedicine, and biotechnology. The field includes the chemistry of carbohydrates, the enzymology of glycan formation and degradation, the recognition of glycans by specific proteins, roles of glycans in complex biological systems, and their analysis or manipulation by various techniques. The third edition of this primary textbook in the field continues in the prior tradition, seeking to provide basic overview of Glycobiology, directed towards the advanced undergraduate or the beginning graduate-level student of molecular and cellular biology and biomedicine. While efforts have been made to avoid a major increase in overall length of the text, substantial changes and improvements include the following: broader focus on all lineages of life forms in nature; wider range of topics, ranging from biology and medicine to chemistry and materials science; expanded international editorial board representing a wider range of expertise; wider range of contributing authors with expertise in specific areas; greatly expanded monosaccharide symbol nomenclature for the representation of glycans; and greater attention to informatics, and relevance to exploration of the glycome.
Copyright 2015-2017 by The Consortium of Glycobiology Editors, La Jolla, California. All rights reserved.
Sections
- Foreword: Propelling a Field Forward
- Preface
-
Praise for the Previous Editions of
Essentials of Glycobiology -
Advance Comments on the Third Edition of
Essentials of Glycobiology - Contributors
- Consultant Reviewers
- Classic Books and Monographs
- Abbreviations
- Front Cover Artwork
- General Principles
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Structure and Biosynthesis
- 9. N-Glycans
- 10. O-GalNAc Glycans
- 11. Glycosphingolipids
- 12. Glycosylphosphatidylinositol Anchors
- 13. Other Classes of Eukaryotic Glycans
- 14. Structures Common to Different Glycans
- 15. Sialic Acids and Other Nonulosonic Acids
- 16. Hyaluronan
- 17. Proteoglycans and Sulfated Glycosaminoglycans
- 18. Nucleocytoplasmic Glycosylation
- 19. The O-GlcNAc Modification
- Glycans in Evolution and Development
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Glycan-Binding Proteins
- 28. Discovery and Classification of Glycan-Binding Proteins
- 29. Principles of Glycan Recognition
- 30. Structural Biology of Glycan Recognition
- 31. R-Type Lectins
- 32. L-Type Lectins
- 33. P-Type Lectins
- 34. C-Type Lectins
- 35. I-Type Lectins
- 36. Galectins
- 37. Microbial Lectins: Hemagglutinins, Adhesins, and Toxins
- 38. Proteins That Bind Sulfated Glycosaminoglycans
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Glycans in Physiology and Disease
- 39. Glycans in Glycoprotein Quality Control
- 40. Free Glycans as Signaling Molecules
- 41. Glycans in Systemic Physiology
- 42. Bacterial and Viral Infections
- 43. Parasitic Infections
- 44. Genetic Disorders of Glycan Degradation
- 45. Genetic Disorders of Glycosylation
- 46. Glycans in Acquired Human Diseases
- 47. Glycosylation Changes in Cancer
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Methods and Applications
- 48. Glycan-Recognizing Probes as Tools
- 49. Glycosylation Mutants of Cultured Mammalian Cells
- 50. Structural Analysis of Glycans
- 51. Glycomics and Glycoproteomics
- 52. Glycoinformatics
- 53. Chemical Synthesis of Glycans and Glycoconjugates
- 54. Chemoenzymatic Synthesis of Glycans and Glycoconjugates
- 55. Chemical Tools for Inhibiting Glycosylation
- 56. Glycosylation Engineering
- 57. Glycans in Biotechnology and the Pharmaceutical Industry
- 58. Glycans in Nanotechnology
- 59. Glycans in Bioenergy and Materials Science
- 60. Future Directions in Glycosciences
- Online Appendix 1A. Some Important Milestones in the History of Glycobiology
- Online Appendix 1B. Symbol Nomenclature for Glycans (SNFG)
- Online Appendix 12A. Examples of GPI-Anchored Proteins
- Online Appendix 12B. Complex and Varied Structures of Glycosylphosphatidylinositol (GPI) Anchors.
- Online Appendix 27A. Glycosylation Genes Essential for Mouse Embryonic Development
- Online Appendix 28A. Comparison of Two Major Classes of Glycan-Binding Proteins
- Online Appendix 38A. Molecular Dynamic Simulations
- Online Appendix 45A. Known Human Glycosylation Disorders
- Online Appendix 52A. Organizations and Publications Adopting SNFG
- Glossary
- Study Guide
- Errata
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