Autoimmune atherosclerosis in 3D: How it develops, how to diagnose and what to do

doi:10.1016/j.autrev.2016.03.014

Review

. 2016 Jul;15(7):756-69.

doi: 10.1016/j.autrev.2016.03.014. Epub 2016 Mar 12.

Autoimmune atherosclerosis in 3D: How it develops, how to diagnose and what to do

Zoltán Szekanecz¹, György Kerekes², Edit Végh³, Zsófia Kardos⁴, Zsuzsa Baráth⁴, László Tamási⁴, Yehuda Shoenfeld⁵

Affiliations

¹ University of Debrecen Faculty of Medicine, Institute of Medicine, Department of Rheumatology, Hungary. Electronic address: szekanecz.zoltan@med.unideb.hu.
² University of Debrecen Faculty of Medicine, Institute of Medicine, Department of Angiology, Debrecen, Hungary.
³ University of Debrecen Faculty of Medicine, Institute of Medicine, Department of Rheumatology, Hungary.
⁴ Department of Rheumatology, Semmelweis Teaching Hospital, Miskolc, Hungary.
⁵ Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.

PMID: 26979271
DOI: 10.1016/j.autrev.2016.03.014

Review

Autoimmune atherosclerosis in 3D: How it develops, how to diagnose and what to do

Zoltán Szekanecz et al. Autoimmun Rev. 2016 Jul.

. 2016 Jul;15(7):756-69.

doi: 10.1016/j.autrev.2016.03.014. Epub 2016 Mar 12.

Authors

Zoltán Szekanecz¹, György Kerekes², Edit Végh³, Zsófia Kardos⁴, Zsuzsa Baráth⁴, László Tamási⁴, Yehuda Shoenfeld⁵

Affiliations

¹ University of Debrecen Faculty of Medicine, Institute of Medicine, Department of Rheumatology, Hungary. Electronic address: szekanecz.zoltan@med.unideb.hu.
² University of Debrecen Faculty of Medicine, Institute of Medicine, Department of Angiology, Debrecen, Hungary.
³ University of Debrecen Faculty of Medicine, Institute of Medicine, Department of Rheumatology, Hungary.
⁴ Department of Rheumatology, Semmelweis Teaching Hospital, Miskolc, Hungary.
⁵ Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.

PMID: 26979271
DOI: 10.1016/j.autrev.2016.03.014

Abstract

Autoimmune-inflammatory rheumatic diseases, such as rheumatoid arthritis (RA) have been associated with autoimmune atherosclerosis leading to increased cardiovascular risk. Traditional risk factors, genetics, as well as the role of systemic inflammation including inflammatory cells, cytokines, chemokines, proteases, autoantibodies, adhesion receptors and others have been implicated in the development of these vascular pathologies. Cardiovascular risk may be determined by the use of currently available tools. In addition, non-invasive assessment of vascular pathophysiology by imaging, as well as laboratory biomarkers can help to refine risk assessment. With respect to prevention and therapy, traditional vasculoprotection using statins, ACE inhibitors, aspirin should be applied to patients at risk. Non-steroidal antiinflammatory drugs and corticosteroids may be pro-atherogenic, on the other hand, they may also be beneficial due to their anti-inflammatory nation. Traditional and biologic DMARDs may have significant vascular and metabolic effects. Decreasing inflammatory activity by any of these agents may lead to better CV outcome. The official EULAR recommendations on the assessment and management of cardiovascular disease in arthritides may guide the rheumatologist during the process of CV screening, prevention and treatment.

Keywords: Arthritis; Atherosclerosis; Autoimmunity; Biologics; Cardiovascular disease; Risk assessment.

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Autoimmune atherosclerosis in 3D: How it develops, how to diagnose and what to do

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Autoimmune atherosclerosis in 3D: How it develops, how to diagnose and what to do

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