TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance

doi:10.1111/all.12871

Review

. 2016 Jun;71(6):758-64.

doi: 10.1111/all.12871. Epub 2016 Apr 15.

TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance

X Zhang^{1

2

3}, J Gu³, F-S Yu^{4

5}, L Zhou^{1

2

6

7}, Q-S Mi^{1

2

6

7}

Affiliations

¹ Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.
² Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
³ Department of Dermatology, Second Military Medical University Changhai Hospital, Shanghai, China.
⁴ Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI, USA.
⁵ Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA.
⁶ Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
⁷ Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI, USA.

PMID: 26948524
PMCID: PMC5016192
DOI: 10.1111/all.12871

Review

TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance

X Zhang et al. Allergy. 2016 Jun.

. 2016 Jun;71(6):758-64.

doi: 10.1111/all.12871. Epub 2016 Apr 15.

Authors

X Zhang^{1

2

3}, J Gu³, F-S Yu^{4

5}, L Zhou^{1

2

6

7}, Q-S Mi^{1

2

6

7}

Affiliations

¹ Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.
² Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
³ Department of Dermatology, Second Military Medical University Changhai Hospital, Shanghai, China.
⁴ Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI, USA.
⁵ Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA.
⁶ Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
⁷ Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI, USA.

PMID: 26948524
PMCID: PMC5016192
DOI: 10.1111/all.12871

Abstract

Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. Transforming growth factor-β1 (TGF-β1) has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This review focuses on the recent discoveries in TGF-β1-mediated LC development and maintenance, with special attention to the involved transcription factors and related regulators.

Keywords: TGF-β1; development; langerhans cells; transcription factors.

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Conflict of interest statement

The authors declared no conflict of interest.

Figures

**Figure 1. TGF-β1-mediated LC differentiation**
A number of transcription factors and regulators form a network in TGF-β1-regulated LC development and maintenance, in which transcription factor PU.1 is a core factor. Red plus indicates a promoting role in LC differentiation, and green minus indicates an inhibitive role. Solid blue arrows indicate positive stimulatory functions that have been proven or suggested by previous reports. Dotted arrows indicate hypothesized relationships. Dark-grey lines indicate negative regulation. Peachblow rims indicate that the results derive from mouse experiments. Orange rims indicate that the results derive from human experiments. Purple rims indicate that the results derived from both mouse and human experiments.

See this image and copyright information in PMC

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References

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1. Romani N, Clausen BE, Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev. 2010;234:120–141. - PMC - PubMed
1. Hoeffel G, Wang Y, Greter M, et al. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med. 2012;209:1167–1181. - PMC - PubMed
1. Gomez Perdiguero E, Klapproth K, Schulz C, et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature. 2015;518:547–551. - PMC - PubMed
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[1] Igyarto BZ, Kaplan DH. Antigen presentation by Langerhans cells. Curr Opin Immunol. 2013;25:115–119. - PMC - PubMed

[2] Igyarto BZ, Kaplan DH. Antigen presentation by Langerhans cells. Curr Opin Immunol. 2013;25:115–119. - PMC - PubMed

[3] Romani N, Clausen BE, Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev. 2010;234:120–141. - PMC - PubMed

[4] Romani N, Clausen BE, Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev. 2010;234:120–141. - PMC - PubMed

[5] Hoeffel G, Wang Y, Greter M, et al. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med. 2012;209:1167–1181. - PMC - PubMed

[6] Hoeffel G, Wang Y, Greter M, et al. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med. 2012;209:1167–1181. - PMC - PubMed

[7] Gomez Perdiguero E, Klapproth K, Schulz C, et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature. 2015;518:547–551. - PMC - PubMed

[8] Gomez Perdiguero E, Klapproth K, Schulz C, et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature. 2015;518:547–551. - PMC - PubMed

[9] Schuster C, Mildner M, Mairhofer M, et al. Human embryonic epidermis contains a diverse Langerhans cell precursor pool. Development. 2014;141:807–815. - PubMed

[10] Schuster C, Mildner M, Mairhofer M, et al. Human embryonic epidermis contains a diverse Langerhans cell precursor pool. Development. 2014;141:807–815. - PubMed

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TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance

Affiliations

TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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Cited by

References

Publication types

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Grants and funding

LinkOut - more resources

Full Text Sources

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