Genetic characteristics of coxsackievirus A16 associated with hand, foot, and mouth disease in Nanjing, China
- PMID: 26927459
- DOI: 10.3855/jidc.6876
Genetic characteristics of coxsackievirus A16 associated with hand, foot, and mouth disease in Nanjing, China
Abstract
Introduction: Coxsackievirus A16 (CVA16) is a main pathogen in hand, foot, and mouth disease (HFMD) worldwide. This study intended to clarify the genetic characteristics of CVA16 associated with HFMD in a defined area in Nanjing, China.
Methodology: A total of 175 CVA16 strains isolated from throat swabs between 2011 and 2013 were obtained through sentinel hospitals in Nanjing. Multiplex polymerase chain reaction (PCR) was used to amplify the VP1 sequence of local CVA16 strains, and their genetic relationship with 138 CVA16 strains isolated in China and other countries of the world was compared.
Results: Phylogenetic analysis based on complete VP1 sequences revealed that subgenotype B1a and B1b were predominantly circulating in Nanjing and B1b strains were spread more widely. The evolution of CVA16 strains is very conservative, with a mean distance of less than 9%. Moreover, six reported conservative regions in VP1 protein were examined, and three of them exhibited high conservation in all CVA16 genotypes except the G-10 prototype and may serve for further vaccine research.
Conclusions: The CVA16 strains circulating in Nanjing, China, in 2011 to 2013 belonged to different genotypes and evolved in a conservative way. To provide further evidence for epidemiological linkage and evolutionary recombination events in CVA16, persistent surveillance of HFMD-associated pathogens is required.
Similar articles
-
[B1a and b1b evolutionary branch of coxsackie virus A16 co-prevailed in Inner Mongolia Autonomous Region].Bing Du Xue Bao. 2013 Jun;29(4):426-31. Bing Du Xue Bao. 2013. PMID: 23895009 Chinese.
-
Prevalence of Coxsackievirus A6 and Enterovirus 71 in Hand, Foot and Mouth Disease in Nanjing, China in 2013.Pediatr Infect Dis J. 2015 Sep;34(9):951-7. doi: 10.1097/INF.0000000000000794. Pediatr Infect Dis J. 2015. PMID: 26090576
-
[Analysis on genetic character of coxsackievirus A16 strains isolated in Shanghai in 2002].Zhongguo Yi Miao He Mian Yi. 2009 Apr;15(2):135-40. Zhongguo Yi Miao He Mian Yi. 2009. PMID: 20077659 Chinese.
-
[Prevalence and Analyses of the Changing Etiology of Hand, Foot and Mouth Disease in China].Bing Du Xue Bao. 2015 Sep;31(5):554-9. Bing Du Xue Bao. 2015. PMID: 26738295 Review. Chinese.
-
[Research advances in molecular epidemiology and vaccines of Coxsackievirus A16].Bing Du Xue Bao. 2014 Jul;30(4):483-8. Bing Du Xue Bao. 2014. PMID: 25272607 Review. Chinese.
Cited by
-
Molecular surveillance of coxsackievirus A16 in southern China, 2008-2019.Arch Virol. 2021 Jun;166(6):1653-1659. doi: 10.1007/s00705-021-05052-8. Epub 2021 Apr 1. Arch Virol. 2021. PMID: 33796884
-
Co-circulation of coxsackieviruses A-6, A-10, and A-16 causes hand, foot, and mouth disease in Guangzhou city, China.BMC Infect Dis. 2020 Apr 7;20(1):271. doi: 10.1186/s12879-020-04992-x. BMC Infect Dis. 2020. PMID: 32264839 Free PMC article.
-
Scavenger receptor class a, member 3 is associated with severity of hand, foot, and mouth disease in a case-control study.Medicine (Baltimore). 2019 Oct;98(40):e17471. doi: 10.1097/MD.0000000000017471. Medicine (Baltimore). 2019. PMID: 31577778 Free PMC article.
-
Coxsackievirus A6 strains causing an outbreak of hand-foot-and-mouth disease in Northeastern Brazil in 2018.Rev Inst Med Trop Sao Paulo. 2022 Feb 21;64:e16. doi: 10.1590/S1678-9946202264016. eCollection 2022. Rev Inst Med Trop Sao Paulo. 2022. PMID: 35195198 Free PMC article.
-
Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015.Emerg Infect Dis. 2018 Mar;24(3):432-42. doi: 10.3201/eid2403.171303. Emerg Infect Dis. 2018. PMID: 29460747 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
