Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr;17(3):187-92.
doi: 10.1038/gene.2016.7. Epub 2016 Feb 18.

The early onset of type 1 autoimmune hepatitis has a strong genetic influence: role of HLA and KIR genes

A Podhorzer  1 , N Paladino  1 , M L Cuarterolo  2 , H A Fainboim  3 , S Paz  3 , G Theiler  1 , M Capucchio  1 , S I López  2 , A Machicote  1 , S Montal  4 , G Podesta  4 , L Fainboim  1   5
Affiliations

The early onset of type 1 autoimmune hepatitis has a strong genetic influence: role of HLA and KIR genes

A Podhorzer et al. Genes Immun. 2016 Apr.

Abstract

We have previously reported a strong association between HLA-DRB1*1301 and type 1 pediatric autoimmune hepatitis (PAH) and between HLA-DR*0405 and adult autoimmune hepatitis (AAH). Because human killer cell immunoglobulin-like receptors are known to be associated with susceptibility to autoimmune diseases, we investigated the frequencies of HLA-A, B, C, DRB1 and KIR genes in 144 type 1 PAH and 86 AAH patients, which were compared with 273 healthy controls. We demonstrated in PAH the increased frequency of the functional form of KIR2DS4-Full Length (KIR2DS4-FL), which in combination with HLA-DRB1*1301 revealed a strong synergistic effect (odds ratio=36.5). PAH-KIR2DS4-FL+ subjects have shown an increased frequency of their putative HLA-C*02, 04 and 06 ligands. KIR analysis of PAH also revealed a decreased frequency of KIR2DL2 gene and its ligand. In contrast, AAH cases have shown a weaker increased frequency of KIR2DS4-FL, a lack of synergistic effect with HLA class II antigens and a moderate association with HLA-DRB1*0405. Of note, we demonstrated that liver T cells have a unique pattern of KIR expression. These results show a KIR gene involved in autoimmune hepatitis and suggest a stronger genetic influence for the early onset type I autoimmune hepatitis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Invest Dermatol. 2005 Oct;125(4):721-30 - PubMed
    1. Hepatology. 1997 Feb;25(2):317-23 - PubMed
    1. Tissue Antigens. 2007 Jun;69(6):568-76 - PubMed
    1. Hum Immunol. 2007 Feb;68(2):128-34 - PubMed
    1. J Hepatol. 2004 Jun;40(6):904-9 - PubMed

LinkOut - more resources