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. 1989 Nov 1;263(3):989-92.
doi: 10.1042/bj2630989.

Cytosolic ferritin and lipid-associated ferritin are metabolically different in guinea-pig livers

B E Cham  1 , H P Roeser, A C Nikles
Affiliations

Cytosolic ferritin and lipid-associated ferritin are metabolically different in guinea-pig livers

B E Cham et al. Biochem J. .

Abstract

A distinct pool of liver ferritin has been described in man, guinea pigs and rats [Cham, Roeser, Nikles & Ridgway (1986) Clin. Chim. Acta 158, 71-79]. This ferritin accounts for approx. 30% of total intracellular ferritin. It differs from previously described cytosolic and 'microsomal-fraction' ferritin by its firm association with lipid and by the absence of heat-stability at 75 degrees C. The present study demonstrates that cytosolic ferritin and lipid-associated ferritin in guinea-pig livers have distinctly different rates of turnover. Cytosolic ferritin has a rate of turnover approx. 3.5 times as high as lipid-associated ferritin. The apparent metabolic heterogeneity suggests that the two forms of ferritin may have different functional roles.

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References

    1. J Biol Chem. 1966 Aug 10;241(15):3630-7 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. J Biol Chem. 1971 Feb 25;246(4):1025-31 - PubMed
    1. J Biol Chem. 1972 Aug 25;247(16):5234-42 - PubMed
    1. Biochem J. 1973 Jan;131(1):51-9 - PubMed

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