Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Apr;73(8):1547-67.
doi: 10.1007/s00018-016-2134-0. Epub 2016 Feb 5.

Specification and function of hemogenic endothelium during embryogenesis

Emily Gritz  1   2 , Karen K Hirschi  3
Affiliations
Review

Specification and function of hemogenic endothelium during embryogenesis

Emily Gritz et al. Cell Mol Life Sci. 2016 Apr.

Abstract

Hemogenic endothelium is a specialized subset of developing vascular endothelium that acquires hematopoietic potential and can give rise to multilineage hematopoietic stem and progenitor cells during a narrow developmental window in tissues such as the extraembryonic yolk sac and embryonic aorta-gonad-mesonephros. Herein, we review current knowledge about the historical and developmental origins of hemogenic endothelium, the molecular events that govern hemogenic specification of vascular endothelial cells, the generation of multilineage hematopoietic stem and progenitor cells from hemogenic endothelium, and the potential for translational applications of knowledge gained from further study of these processes.

Keywords: Developmental hematopoiesis; Embryogenesis; Endothelial to hematopoietic transition; Hemogenic endothelium.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Summary of regulation of primitive hematopoietic specification and generation of hematopoietic stem cells during embryonic development. a Schematic representation of endothelial layer of developing vascular wall (pink), listed are intra- and extraembryonic sources of vascular endothelial cells with hemogenic potential (blue box). b Schematic representation of progression of events and molecular signals governing hemogenic specification (orange boxes) and c endothelial to hematopoietic transition (green boxes), ending with generation of intra-vascular hematopoietic clusters and multi-lineage hematopoietic stem and progenitor cells (HSPC)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Marcelo KL, Goldie LC, Hirschi KK. Regulation of endothelial cell differentiation and specification. Circ Res. 2013;112(9):1272–1287. doi: 10.1161/CIRCRESAHA.113.300506. - DOI - PMC - PubMed
    1. Lawson KA, Meneses JJ, Pedersen RA. Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development (Cambridge, England) 1991;113(3):891–911. - PubMed
    1. Palis J, Robertson S, Kennedy M, Wall C, Keller G. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development (Cambridge, England) 1999;126(22):5073–5084. - PubMed
    1. Corbel C, Salaun J, Belo-Diabangouaya P, Dieterlen-Lievre F. Hematopoietic potential of the pre-fusion allantois. Dev Biol. 2007;301(2):478–488. doi: 10.1016/j.ydbio.2006.08.069. - DOI - PubMed
    1. Zeigler BM, Sugiyama D, Chen M, Guo Y, Downs KM, Speck NA. The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential. Development (Cambridge, England) 2006;133(21):4183–4192. doi: 10.1242/dev.02596. - DOI - PubMed

MeSH terms