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Meta-Analysis
. 2016 Mar 15;7(11):12525-36.
doi: 10.18632/oncotarget.7123.

Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis

Zongguo Yang  1 , Liping Zhuang  2   3 , Yunfei Lu  1 , Qingnian Xu  1 , Bozong Tang  1 , Xiaorong Chen  1
Affiliations
Meta-Analysis

Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis

Zongguo Yang et al. Oncotarget. .

Abstract

Basal core promoter (BCP) A1762T/G1764A dual mutations in hepatocarcinogenesis remain controversial. Published studies up to June 1, 2015 investigating the frequency of A1762T/G1764A dual mutations from chronic hepatitis B virus (HBV) infection, including hepatocellular carcinoma (HCC), were systematically identified. A total of 10,240 patients with chronic HBV infection, including 3729 HCC cases, were included in 52 identified studies. HCC patients had a higher frequency of BCP A1762T/G1764A dual mutations compared with asymptomatic HBsAg carriers (ASC) and patients with chronic hepatitis B (CHB) and liver cirrhosis (LC) (OR = 5.59, P < 0.00001; OR = 2.87, P < 0.00001; OR = 1.55, P = 0.02, respectively). No statistically significant difference was observed in the frequency of A1762T/G1764A dual mutations in cirrhotic HCC versus non-cirrhotic HCC patients (OR = 2.06, P = 0.05). Chronic HBV-infected patients and HCC patients with genotype B had a significantly lower risk of A1762T/G1764A dual mutations compared with patients with genotype C (OR = 0.30, P < 0.0001 and OR = 0.34, P = 0.04, respectively). In HBV genotype C subjects, A1762T/G1764A dual mutations contributed to significantly higher risk for HCC developing compared with non-mutation ones (OR = 3.47, P < 0.00001). In conclusion, A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma, particularly in an HBV genotype C population, even without progression to cirrhosis.

Keywords: A1762T/G1764A; basal core promoter; hepatitis B virus X protein; hepatocellular carcinoma; mutation.

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Conflict of interest statement

CONFLICTS OF INTEREST

There is no conflict of interest.

Figures

Figure 1
Figure 1. Flow program of study selection
Figure 2
Figure 2. BCP A1762T/G1764A dual mutations in HBV genotype B and C from chronic HBV infection patients, including HCC
Figure 3
Figure 3. HCC occurrence between BCP A1762T/G1764A dual mutation and non-BCP dual mutation patients with HBV genotype C and genotype B
Figure 4
Figure 4. Comparison of BCP A1762T/G1764A dual mutations grouped by HBeAg status from chronic HBV infection patients, including HCC
See this image and copyright information in PMC

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