Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling
- PMID: 26844774
- DOI: 10.1016/j.bbamcr.2016.01.025
Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling
Abstract
Melanoma has markedly increased worldwide during the past several decades in the Caucasian population and is responsible for 80% of skin cancer deaths. Considering that metastatic melanoma is almost completely resistant to most current therapies and is linked with a poor patient prognosis, it is crucial to further investigate potential molecular targets. Major cell-autonomous drivers in the pathogenesis of this disease include the classical MAPK (i.e., RAS-RAF-MEK-ERK), WNT, and PI3K signaling pathways. These pathways play a major role in defining the progression of melanoma, and some have been the subject of recent pharmacological strategies to treat this belligerent disease. This review describes the latest advances in the understanding of melanoma progression and the major molecular pathways involved. In addition, we discuss the roles of emerging molecular players that are involved in melanoma pathogenesis, including the functional role of the melanoma tumor antigen, p97/MFI2 (melanotransferrin).
Keywords: BRAF; EMT; MAPK; Melanoma; PI3K; WNT.
Copyright © 2016 Elsevier B.V. All rights reserved.
Similar articles
-
[Future targeting of the RAS/RAF/MEK/ERK signaling pathway in oncology: the example of melanoma].Bull Acad Natl Med. 2014 Feb;198(2):321-36; discussion 337-8. Bull Acad Natl Med. 2014. PMID: 26263707 French.
-
Ras, Raf, and MAP kinase in melanoma.Adv Anat Pathol. 2013 Jul;20(4):217-26. doi: 10.1097/PAP.0b013e3182976c94. Adv Anat Pathol. 2013. PMID: 23752084 Review.
-
Targeting RAS/RAF/MEK/ERK signaling in metastatic melanoma.IUBMB Life. 2013 Sep;65(9):748-58. doi: 10.1002/iub.1193. Epub 2013 Jul 29. IUBMB Life. 2013. PMID: 23893853 Review.
-
Recent discoveries in the genetics of melanoma and their therapeutic implications.Arch Immunol Ther Exp (Warsz). 2007 Nov-Dec;55(6):363-72. doi: 10.1007/s00005-007-0043-5. Epub 2007 Dec 3. Arch Immunol Ther Exp (Warsz). 2007. PMID: 18060370 Free PMC article. Review.
-
Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model.Dis Model Mech. 2009 Jul-Aug;2(7-8):399-411. doi: 10.1242/dmm.001149. Epub 2009 May 26. Dis Model Mech. 2009. PMID: 19470611
Cited by
-
Cell Adhesion Molecules in Plasticity and Metastasis.Mol Cancer Res. 2021 Jan;19(1):25-37. doi: 10.1158/1541-7786.MCR-20-0595. Epub 2020 Oct 1. Mol Cancer Res. 2021. PMID: 33004622 Free PMC article. Review.
-
Mechanistically Coupled PK (MCPK) Model to Describe Enzyme Induction and Occupancy Dependent DDI of Dabrafenib Metabolism.Pharmaceutics. 2022 Jan 28;14(2):310. doi: 10.3390/pharmaceutics14020310. Pharmaceutics. 2022. PMID: 35214043 Free PMC article.
-
Revisiting the melanomagenic pathways and current therapeutic approaches.Mol Biol Rep. 2022 Oct;49(10):9651-9671. doi: 10.1007/s11033-022-07412-2. Epub 2022 Apr 10. Mol Biol Rep. 2022. PMID: 35397763 Review.
-
Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma.Biomolecules. 2022 Jan 11;12(1):114. doi: 10.3390/biom12010114. Biomolecules. 2022. PMID: 35053262 Free PMC article.
-
Hey1 promotes migration and invasion of melanoma cells via GRB2/PI3K/AKT signaling cascade.J Cancer. 2021 Oct 11;12(23):6979-6988. doi: 10.7150/jca.60974. eCollection 2021. J Cancer. 2021. PMID: 34729100 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous
