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Review
. 2016 Apr;48(4):915-928.
doi: 10.1007/s00726-016-2171-x. Epub 2016 Jan 18.

Rag GTPase in amino acid signaling

Joungmok Kim  1 , Eunjung Kim  2
Affiliations
Review

Rag GTPase in amino acid signaling

Joungmok Kim et al. Amino Acids. 2016 Apr.

Abstract

Rag small GTPases were identified as the sixth subfamily of Ras-related GTPases. Compelling evidence suggests that Rag heterodimer (RagA/B and RagC/D) plays an important role in amino acid signaling toward mechanistic target of rapamycin complex 1 (mTORC1), which is a central player in the control of cell growth in response to a variety of environmental cues, including growth factors, cellular energy/oxygen status, and amino acids. Upon amino acid stimulation, active Rag heterodimer (RagA/B(GTP)-RagC/D(GDP)) recruits mTORC1 to the lysosomal membrane where Rheb resides. In this review, we provide a current understanding on the amino acid-regulated cell growth control via Rag-mTORC1 with recently identified key players, including Ragulator, v-ATPase, and GATOR complexes. Moreover, the functions of Rag in physiological systems and in autophagy are discussed.

Keywords: Amino acids; Cell growth; Rag; Small GTPase; mTOR.

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