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. 2016 Feb;26(2):151-154.e4.
doi: 10.1016/j.annepidem.2015.11.004. Epub 2015 Dec 11.

Temporal trends of esophageal disorders by age in the Cerner Health Facts database

Jessica L Petrick  1 , Tuyet Nguyen  2 , Michael B Cook  3
Affiliations

Temporal trends of esophageal disorders by age in the Cerner Health Facts database

Jessica L Petrick et al. Ann Epidemiol. 2016 Feb.

Abstract

Purpose: Esophageal adenocarcinoma incidence has increased approximately 600% over the last 4 decades in the United States. Little research has been conducted on the temporal trends of gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE), yet it is important to establish whether these conditions have also increased with time or differ by age.

Methods: The Cerner Health Facts(®) database contains information on 35 million patients between 2001 and 2010. GERD, BE, and esophageal cancer (EC) cases were defined using International Classification of Diseases, ninth edition codes. We calculated age-adjusted rates and 95% confidence intervals for GERD, BE, and EC.

Results: In this population, the overall, all-age rate per 100,000 encounters for GERD was 711.9, BE was 21.6, and EC was 6.1. During 2001-2010, GERD rates increased by approximately 50% and EC rates more than doubled, but BE rates declined by approximately 40%. Trends were similar by age, and all rates were higher in Caucasians and males.

Conclusions: These data indirectly support the idea that increased incidence of EC may be partially due to GERD and raise the provocative hypothesis that BE rates may be decreasing possibly as a forerunner of continued stabilization of esophageal adenocarcinoma rates and a possible subsequent decline.

Keywords: Barrett's esophagus; Esophageal cancer; Gastroesophageal reflux disease; Temporal trends.

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Figures

Figure 1
Figure 1
Temporal trends of gastroesophageal reflux, Barrett's esophagus and esophageal cancer overall (A), and by age (B–D), Cerner Health Facts® Database, 2001–2010.
Figure 1
Figure 1
Temporal trends of gastroesophageal reflux, Barrett's esophagus and esophageal cancer overall (A), and by age (B–D), Cerner Health Facts® Database, 2001–2010.
Figure 1
Figure 1
Temporal trends of gastroesophageal reflux, Barrett's esophagus and esophageal cancer overall (A), and by age (B–D), Cerner Health Facts® Database, 2001–2010.
Figure 1
Figure 1
Temporal trends of gastroesophageal reflux, Barrett's esophagus and esophageal cancer overall (A), and by age (B–D), Cerner Health Facts® Database, 2001–2010.
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References

    1. Devesa SS, Blot WJ, Fraumeni JF., Jr Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer. 1998 Nov 15;83(10):2049–53. - PubMed
    1. Brown LM, Devesa SS, Chow WH. Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. J Natl Cancer Inst. 2008 Aug 20;100(16):1184–7. - PMC - PubMed
    1. Simard EP, Ward EM, Siegel R, Jemal A. Cancers with increasing incidence trends in the United States: 1999 through 2008. CA: a cancer journal for clinicians. 2012 Mar-Apr;62(2):118–28. - PubMed
    1. Clouston AD. Timely topic: Premalignant lesions associated with adenocarcinoma of the upper gastrointestinal tract. Pathology. 2001 Aug;33(3):271–7. - PubMed
    1. Riddell RH. The genesis of Barrett esophagus: has a histologic transition from gastroesophageal reflux disease-damaged epithelium to columnar metaplasia ever been seen in humans? Archives of pathology & laboratory medicine. 2005 Feb;129(2):164–9. - PubMed

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