Uniform lineage of oligodendrogliomas
- PMID: 2675625
- PMCID: PMC1879866
Uniform lineage of oligodendrogliomas
Abstract
Experimental observations provide evidence that galactocerebroside-containing (GC+) oligodendrocytes and glial fibrillary acidic protein-containing (GFAP+) type 2 astrocytes are derived from A2B5+ progenitor cells. Because the cytomorphologic features of oligodendrogliomas resemble those of non-neoplastic oligodendrocytes, it was speculated that neoplastic oligodendroglial cells also have A2B5+ lineage. This hypothesis was investigated by immunostaining histopathologic sections with monoclonal antibodies to GC, A2B5, and GFAP. In 28 tumors, ubiquitous immunolabeling of neoplastic cells with anti-GC and anti-A2B5 was observed. In addition, GFAP+/A2B5+ astrocytes were present in most mixed glial tumors. The findings suggest that oligodendrogliomas, whether or not they contain foci of astrocytoma, are uniformly derived from A2B5+ progenitor cells.
Similar articles
-
Dual lineage of astrocytomas.Am J Pathol. 1989 Sep;135(3):517-27. Am J Pathol. 1989. PMID: 2551172 Free PMC article.
-
A2B5 lineages of human astrocytic tumors and their recurrence.Int J Oncol. 2003 Aug;23(2):353-61. Int J Oncol. 2003. PMID: 12851684
-
In vitro identification and functional characterization of glial precursor cells in human gliomas.Neuropathol Appl Neurobiol. 2006 Apr;32(2):189-202. doi: 10.1111/j.1365-2990.2006.00740.x. Neuropathol Appl Neurobiol. 2006. PMID: 16599947
-
[Clinicopathological study of oligodendroglioma with special reference to immunohistochemical investigation].No Shinkei Geka. 1988 Aug;16(9):1029-35. No Shinkei Geka. 1988. PMID: 2462693 Japanese.
-
Current diagnostic concepts of astrocytic tumors.J Neuropathol Exp Neurol. 1992 Nov;51(6):644-57. doi: 10.1097/00005072-199211000-00008. J Neuropathol Exp Neurol. 1992. PMID: 1362439 Review. No abstract available.
Cited by
-
GFAP expression in the subcutaneous tumors of immature glial cell line (HITS glioma) derived from ENU-induced rat glioma.J Neurooncol. 1993 Sep;17(3):191-204. doi: 10.1007/BF01049975. J Neurooncol. 1993. PMID: 8164056
-
Glial ontogeny and glial neoplasia: the search for closure.J Neurooncol. 1997 Aug;34(1):5-22. doi: 10.1023/a:1005751018617. J Neurooncol. 1997. PMID: 9210049 Review.
-
Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo.Am J Pathol. 2000 Sep;157(3):1031-7. doi: 10.1016/S0002-9440(10)64615-9. Am J Pathol. 2000. PMID: 10980141 Free PMC article.
-
Combined treatment modality for anaplastic oligodendroglioma: a phase II study.J Neurooncol. 1999 Jun;43(2):179-85. doi: 10.1023/a:1006206800947. J Neurooncol. 1999. PMID: 10533731 Clinical Trial.
-
Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors.Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10361-6. doi: 10.1073/pnas.96.18.10361. Proc Natl Acad Sci U S A. 1999. PMID: 10468613 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous