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Review
. 2016 May:124:141-149.
doi: 10.1016/j.biochi.2015.12.016. Epub 2015 Dec 29.

From infancy to aging: Biological and behavioral modifiers of Fetuin-A

Katie N Robinson  1 , Margarita Teran-Garcia  2
Affiliations
Review

From infancy to aging: Biological and behavioral modifiers of Fetuin-A

Katie N Robinson et al. Biochimie. 2016 May.

Abstract

Fetuin-A is a multifunctional protein which inhibits ectopic calcification and insulin receptor phosphorylation. It may also promote insulin resistance by activation of toll-like receptor 4 pro-inflammatory cascade. Increased levels of Fetuin-A have been associated with obesity and related comorbidities such as type 2 diabetes and cardiovascular disease, therefore, it has been suggested as a potential therapeutic target for intervention. However, in addition to its role in disease pathophysiology, Fetuin-A is also important for growth and development. Thus, before evaluating Fetuin-A as a biomarker or pharmacological target, an understanding of Fetuin-A variability throughout the life cycle is essential. This manuscript reviews the current body of knowledge surrounding Fetuin-A throughout the life cycle and discuss challenges to studying Fetuin-A.

Keywords: AHSG; Alpha2-Heremans Schmid glycoprotein; Fetuin-A.

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