Potential roles of fibroblast growth factor 21 in the brain

doi:10.1007/s11011-015-9789-3

Review

. 2016 Apr;31(2):239-48.

doi: 10.1007/s11011-015-9789-3. Epub 2016 Jan 6.

Potential roles of fibroblast growth factor 21 in the brain

Piangkwan Sa-Nguanmoo^{1

2

3}, Nipon Chattipakorn^{1

2

3}, Siriporn C Chattipakorn^{4

5

6}

Affiliations

¹ Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
² Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
³ Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
⁴ Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. scchattipakorn@gmail.com.
⁵ Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. scchattipakorn@gmail.com.
⁶ Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. scchattipakorn@gmail.com.

PMID: 26738728
DOI: 10.1007/s11011-015-9789-3

Review

Potential roles of fibroblast growth factor 21 in the brain

Piangkwan Sa-Nguanmoo et al. Metab Brain Dis. 2016 Apr.

. 2016 Apr;31(2):239-48.

doi: 10.1007/s11011-015-9789-3. Epub 2016 Jan 6.

Authors

Piangkwan Sa-Nguanmoo^{1

2

3}, Nipon Chattipakorn^{1

2

3}, Siriporn C Chattipakorn^{4

5

6}

Affiliations

¹ Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
² Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
³ Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
⁴ Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. scchattipakorn@gmail.com.
⁵ Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. scchattipakorn@gmail.com.
⁶ Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. scchattipakorn@gmail.com.

PMID: 26738728
DOI: 10.1007/s11011-015-9789-3

Abstract

Fibroblast growth factor 21 (FGF21) is an endocrine hormone, playing an important role in the regulation of metabolism. FGF21 is primarily expressed by several tissues, including liver, pancreas, thymus, heart, muscle, adipose tissue, and brain. In addition to the effects of FGF21 in lowering glucose and lipid levels, increasing insulin sensitivity and regulating energy homeostasis in rodents and non-human primate models of diabetes and obesity, previous reports have demonstrated that FGF21 also plays an important role in the brain involving it in potential effects in metabolic regulation, neuroprotection and cognition. In this review, the current available evidence from both in vitro and in vivo investigations regarding the roles of FGF21 and its function in the brain are comprehensively summarized. In addition, the mechanistic insights regarding the roles of FGF21 in the brain and its potential neuroprotective benefits are also presented and discussed.

Keywords: Brain; Cognition; FGF21; Hypothalamus; Metabolism.

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FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice.
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Rühlmann C, Wölk T, Blümel T, Stahn L, Vollmar B, Kuhla A. Rühlmann C, et al. Aging (Albany NY). 2016 Nov 29;8(11):2777-2789. doi: 10.18632/aging.101086. Aging (Albany NY). 2016. PMID: 27902456 Free PMC article.
Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states.
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Salminen A, Kauppinen A, Kaarniranta K. Salminen A, et al. J Mol Med (Berl). 2017 Feb;95(2):123-131. doi: 10.1007/s00109-016-1477-1. Epub 2016 Sep 27. J Mol Med (Berl). 2017. PMID: 27678528 Review.

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[1] Diabetes. 2010 Jul;59(7):1817-24 - PubMed

[2] Diabetes. 2010 Jul;59(7):1817-24 - PubMed

[3] PLoS One. 2012;7(3):e33603 - PubMed

[4] PLoS One. 2012;7(3):e33603 - PubMed

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Potential roles of fibroblast growth factor 21 in the brain

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Potential roles of fibroblast growth factor 21 in the brain

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