Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016;14(6):627-40.
doi: 10.2174/1570159x14666160104142223.

Nutraceuticals against Neurodegeneration: A Mechanistic Insight

Vivekkumar P Dadhania, Priyanka P Trivedi, Ajit Vikram  1 , Durga Nand Tripathi  2
Affiliations
Review

Nutraceuticals against Neurodegeneration: A Mechanistic Insight

Vivekkumar P Dadhania et al. Curr Neuropharmacol. 2016.

Abstract

The mechanisms underlying neurodegenerative disorders are complex and multifactorial; however, accumulating evidences suggest few common shared pathways. These common pathways include mitochondrial dysfunction, intracellular Ca2+ overload, oxidative stress and inflammation. Often multiple pathways co-exist, and therefore limit the benefits of therapeutic interventions. Nutraceuticals have recently gained importance owing to their multifaceted effects. These food-based approaches are believed to target multiple pathways in a slow but more physiological manner without causing severe adverse effects. Available information strongly supports the notion that apart from preventing the onset of neuronal damage, nutraceuticals can potentially attenuate the continued progression of neuronal destruction. In this article, we i) review the common pathways involved in the pathogenesis of the toxicants-induced neurotoxicity and neurodegenerative disorders with special emphasis on Alzheimer`s disease (AD), Parkinson`s disease (PD), Huntington`s disease (HD), Multiple sclerosis (MS) and Amyotrophic lateral sclerosis (ALS), and ii) summarize current research advancements on the effects of nutraceuticals against these detrimental pathways.

PubMed Disclaimer

Figures

Fig. (1)
Fig. (1)
A diagrammatic representation of the major pathways involved in neuronal damage and nutraceuticals-mediated neuroprotection.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Fu X.Y., Yang M.F., Cao M.Z., Li D.W., Yang X.Y., Sun J.Y., Zhang Z.Y., Mao L.L., Zhang S., Wang F.Z., Zhang F., Fan C.D., Sun B.L. Strategy to Suppress Oxidative Damage-Induced Neurotoxicity in PC12 Cells by Curcumin: the Role of ROS-Mediated DNA Damage and the MAPK and AKT Pathways. Mol. Neurobiol. 2014 [PMID: 25432891]. - PubMed
    1. Keber U., Klietz M., Carlsson T., Oertel W.H., Weihe E., Schäfer M.K., Höglinger G.U., Depboylu C. Striatal tyrosine hydroxylase-positive neurons are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice. Neuroscience. 2015;298:302–317. [PMID: 25892702]. - PubMed
    1. Kumar A., Leinisch F., Kadiiska M.B., Corbett J., Mason R.P. Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson’s Disease. Mol. Neurobiol. 2015 [PMID: 25952542]. - PMC - PubMed
    1. Mattson M.P., Magnus T. Ageing and neuronal vulnerability. Nat. Rev. Neurosci. 2006;7(4):278–294. [PMID: 16552414]. - PMC - PubMed
    1. Zindo F.T., Joubert J., Malan S.F. Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond. Future Med. Chem. 2015;7(5):609–629. [PMID: 25921401]. - PubMed