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. 2015 Oct 31;11(10):466-73.
doi: 10.6026/97320630011466. eCollection 2015.

Functional prediction of hypothetical proteins in human adenoviruses

Shane Dorden  1 , Padmanabhan Mahadevan  1
Affiliations

Functional prediction of hypothetical proteins in human adenoviruses

Shane Dorden et al. Bioinformation. .

Abstract

Assigning functional information to hypothetical proteins in virus genomes is crucial for gaining insight into their proteomes. Human adenoviruses are medium sized viruses that cause a range of diseases. Their genomes possess proteins with uncharacterized function known as hypothetical proteins. Using a wide range of protein function prediction servers, functional information was obtained about these hypothetical proteins. A comparison of functional information obtained from these servers revealed that some of them produced functional information, while others provided little functional information about these human adenovirus hypothetical proteins. The PFP, ESG, PSIPRED, 3d2GO, and ProtFun servers produced the most functional information regarding these hypothetical proteins.

Keywords: Hypothetical protein; human adenovirus; pathogen; protein function prediction; web server.

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