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. 2015 Dec 11;10(12):e0143757.
doi: 10.1371/journal.pone.0143757. eCollection 2015.

Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis

Masoumeh Nazari  1   2 , Mahdi Mahmoudi  2 , Farzaneh Rahmani  2   3   4 , Masoomeh Akhlaghi  2 , Maani Beigy  2   3   4 , Maryam Azarian  2 , Elmira Shamsian  2 , Maryam Akhtari  2 , Reza Mansouri  1   5
Affiliations

Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis

Masoumeh Nazari et al. PLoS One. .

Abstract

Objectives: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by persistent synovitis, ultimately leading to cartilage and bone degeneration. Natural Killer cells and CD28 null T-cells are suspected as role players in RA pathogenesis. These cells are similar in feature and function, as they both exert their cytotoxic effect via Killer Cell Immunoglobulin- Like Receptors (KIR) on their surface. KIR genes have either an inhibitory or activating effect depending on their intracytoplasmic structure. Herein we genotyped 16 KIR genes, 3 pseudo genes and 6 HLA class І genes as their corresponding ligands in RA patients and control subjects.

Methods: In this case-control study, KIR and HLA genes were genotyped in 400 RA patients and 372 matched healthy controls using sequence-specific primers (SSP-PCR). Differences in the frequency of genes and haplotypes were determined by χ² test.

Results: KIR2DL2, 2DL5a, 2DL5b and activating KIR: KIR2DS5 and 3DS1 were all protective against RA. KIR2DL5 removal from a full Inhibitory KIR haplotype converted the mild protection (OR = 0.56) to a powerful predisposition to RA (OR = 16.47). Inhibitory haplotype No. 7 comprising KIR2DL5 in the absence of KIR2DL1 and KIR2DL3 confers a 14-fold protective effect against RA.

Conclusion: Individuals carrying the inhibitory KIR haplotype No. 6 have a high potential risk for developing RA.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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