Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015;7(8):1365-78.
doi: 10.2217/epi.15.82. Epub 2015 Dec 8.

Emerging roles of ATRX in cancer

L Ashley Watson  1   2   3 , Hannah Goldberg  1   2   3 , Nathalie G Bérubé  1   2   3
Affiliations
Review

Emerging roles of ATRX in cancer

L Ashley Watson et al. Epigenomics. 2015.

Abstract

ATRX was identified over 20 years ago as the gene responsible for a rare developmental disorder characterized by α-thalassemia and intellectual disability. Similarities to the sucrose nonfermentable SNF2 type chromatin remodelers initially suggested a role in transcriptional regulation. However, over the last years, our knowledge of the epigenetic activities of ATRX has expanded steadily. Recent exciting discoveries have propelled ATRX into the limelight of chromatin and telomere biology, development and cancer research. This review summarizes recent breakthroughs in understanding ATRX function in heterochromatin structure, genome stability and its frequent dysregulation in a variety of cancers.

Keywords: ATRX; DAXX; DNA replication; G quadruplexes; alternative lengthening of telomeres; cancer; chromatin; histone H3.3; p53; telomeres.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources