Adipose Tissue: Sanctuary for HIV/SIV Persistence and Replication

doi:10.1016/j.tim.2015.11.001

. 2015 Dec;23(12):748-750.

doi: 10.1016/j.tim.2015.11.001. Epub 2015 Nov 14.

Adipose Tissue: Sanctuary for HIV/SIV Persistence and Replication

Suresh Pallikkuth¹, Mahesh Mohan²

Affiliations

¹ Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1580 NW 10th Avenue BCRI 708, Miami, FL 33136, USA.
² Division of Comparative Pathology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA. Electronic address: mmohan@tulane.edu.

PMID: 26588868
PMCID: PMC4679589
DOI: 10.1016/j.tim.2015.11.001

Adipose Tissue: Sanctuary for HIV/SIV Persistence and Replication

Suresh Pallikkuth et al. Trends Microbiol. 2015 Dec.

. 2015 Dec;23(12):748-750.

doi: 10.1016/j.tim.2015.11.001. Epub 2015 Nov 14.

Authors

Suresh Pallikkuth¹, Mahesh Mohan²

Affiliations

¹ Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1580 NW 10th Avenue BCRI 708, Miami, FL 33136, USA.
² Division of Comparative Pathology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA. Electronic address: mmohan@tulane.edu.

PMID: 26588868
PMCID: PMC4679589
DOI: 10.1016/j.tim.2015.11.001

Abstract

This commentary highlights new findings from a recent study identifying adipose tissue as a potential HIV reservoir and a major site of inflammation during chronic human/simian immunodeficiency virus (HIV/SIV) infection. A concise discussion about upcoming challenges and new research avenues for reducing chronic adipose inflammation during HIV/SIV infection is presented.

Keywords: CD4/CD8 T-cell; HIV/SIV reservoir; adipose tissue; inflammation; macrophage.

PubMed Disclaimer

Cited by

Role of Monocyte/Macrophages during HIV/SIV Infection in Adult and Pediatric Acquired Immune Deficiency Syndrome.
Merino KM, Allers C, Didier ES, Kuroda MJ. Merino KM, et al. Front Immunol. 2017 Dec 5;8:1693. doi: 10.3389/fimmu.2017.01693. eCollection 2017. Front Immunol. 2017. PMID: 29259605 Free PMC article. Review.
HIV and antiretroviral therapy-related fat alterations.
Koethe JR, Lagathu C, Lake JE, Domingo P, Calmy A, Falutz J, Brown TT, Capeau J. Koethe JR, et al. Nat Rev Dis Primers. 2020 Jun 18;6(1):48. doi: 10.1038/s41572-020-0181-1. Nat Rev Dis Primers. 2020. PMID: 32555389 Review.
The interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health.
Quarleri J, Delpino MV. Quarleri J, et al. Geroscience. 2024 Jun;46(3):2915-2932. doi: 10.1007/s11357-023-01058-z. Epub 2024 Jan 8. Geroscience. 2024. PMID: 38191833 Free PMC article. Review.
Morbillivirus-associated lipid pneumonia in Arctic foxes.
Stimmelmayr R, Rotstein DS, Maboni G, Person BT, Sanchez S. Stimmelmayr R, et al. J Vet Diagn Invest. 2018 Nov;30(6):933-936. doi: 10.1177/1040638718797382. Epub 2018 Sep 12. J Vet Diagn Invest. 2018. PMID: 30205787 Free PMC article.
Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons.
Koethe JR, McDonnell W, Kennedy A, Abana CO, Pilkinton M, Setliff I, Georgiev I, Barnett L, Hager CC, Smith R, Kalams SA, Hasty A, Mallal S. Koethe JR, et al. J Acquir Immune Defic Syndr. 2018 Feb 1;77(2):e14-e21. doi: 10.1097/QAI.0000000000001573. J Acquir Immune Defic Syndr. 2018. PMID: 29040163 Free PMC article.

See all "Cited by" articles

References

1. Deeks SG, et al. Towards an HIV cure: a global scientific strategy. Nat Rev Immunol. 2012;12(8):607–614. - PMC - PubMed
1. Chun TW, et al. HIV reservoirs as obstacles and opportunities for an HIV cure. Nat Immunol. 2015;16(6):584–589. - PubMed
1. Damouche A, et al. Adipose tissue is a neglected viral reservoir and an inflammatory site during chronic HIV and SIV infection. PLoS Pathog. 2015;11(9):e1005153. - PMC - PubMed
1. Grant RW, Dixit VD. Adipose tissue as an immunological organ. Obesity (Silver Spring) 2015;23(3):512–518. - PMC - PubMed
1. Belo S, et al. IL-4 and IL-6 levels and adipose tissue distribution in HIV-1 patients under antiretroviral therapy. J Endocrinol Invest. 2015;38(7):779–784. - PubMed

Publication types

Actions

MeSH terms

Grants and funding

OD011104/OD/NIH HHS/United States

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information
Research Materials
- NCI CPTC Antibody Characterization Program

[1] Deeks SG, et al. Towards an HIV cure: a global scientific strategy. Nat Rev Immunol. 2012;12(8):607–614. - PMC - PubMed

[2] Deeks SG, et al. Towards an HIV cure: a global scientific strategy. Nat Rev Immunol. 2012;12(8):607–614. - PMC - PubMed

[3] Chun TW, et al. HIV reservoirs as obstacles and opportunities for an HIV cure. Nat Immunol. 2015;16(6):584–589. - PubMed

[4] Chun TW, et al. HIV reservoirs as obstacles and opportunities for an HIV cure. Nat Immunol. 2015;16(6):584–589. - PubMed

[5] Damouche A, et al. Adipose tissue is a neglected viral reservoir and an inflammatory site during chronic HIV and SIV infection. PLoS Pathog. 2015;11(9):e1005153. - PMC - PubMed

[6] Damouche A, et al. Adipose tissue is a neglected viral reservoir and an inflammatory site during chronic HIV and SIV infection. PLoS Pathog. 2015;11(9):e1005153. - PMC - PubMed

[7] Grant RW, Dixit VD. Adipose tissue as an immunological organ. Obesity (Silver Spring) 2015;23(3):512–518. - PMC - PubMed

[8] Grant RW, Dixit VD. Adipose tissue as an immunological organ. Obesity (Silver Spring) 2015;23(3):512–518. - PMC - PubMed

[9] Belo S, et al. IL-4 and IL-6 levels and adipose tissue distribution in HIV-1 patients under antiretroviral therapy. J Endocrinol Invest. 2015;38(7):779–784. - PubMed

[10] Belo S, et al. IL-4 and IL-6 levels and adipose tissue distribution in HIV-1 patients under antiretroviral therapy. J Endocrinol Invest. 2015;38(7):779–784. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Adipose Tissue: Sanctuary for HIV/SIV Persistence and Replication

Affiliations

Adipose Tissue: Sanctuary for HIV/SIV Persistence and Replication

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials