Human genetics: international projects and personalized medicine
- PMID: 26581075
- DOI: 10.1515/dmpt-2015-0032
Human genetics: international projects and personalized medicine
Abstract
In this article, we present the progress driven by the recent technological advances and new revolutionary massive sequencing technologies in the field of human genetics. We discuss this knowledge in relation with drug response prediction, from the germline genetic variation compiled in the 1000 Genomes Project or in the Genotype-Tissue Expression project, to the phenome-genome archives, the international cancer projects, such as The Cancer Genome Atlas or the International Cancer Genome Consortium, and the epigenetic variation and its influence in gene expression, including the regulation of drug metabolism. This review is based on the lectures presented by the speakers of the Symposium "Human Genetics: International Projects & New Technologies" from the VII Conference of the Spanish Pharmacogenetics and Pharmacogenomics Society, held on the 20th and 21st of April 2015.
Similar articles
-
Pharmacogenetics and pharmacogenomics as tools in cancer therapy.Drug Metab Pers Ther. 2016 Mar;31(1):25-34. doi: 10.1515/dmpt-2015-0042. Drug Metab Pers Ther. 2016. PMID: 26863347 Review.
-
From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions.Drug Metab Rev. 2008;40(2):187-224. doi: 10.1080/03602530801952864. Drug Metab Rev. 2008. PMID: 18464043 Free PMC article. Review.
-
Multiple personal genomes await.Nature. 2010 Apr 1;464(7289):676-7. doi: 10.1038/464676a. Nature. 2010. PMID: 20360717 No abstract available.
-
Genetic advances in medicine: has the promise been fulfilled in general practice?Br J Gen Pract. 2012 Mar;62(596):120-1. doi: 10.3399/bjgp12X629955. Br J Gen Pract. 2012. PMID: 22429411 Free PMC article. No abstract available.
-
Has the revolution arrived?Nature. 2010 Apr 1;464(7289):674-5. doi: 10.1038/464674a. Nature. 2010. PMID: 20360716 Free PMC article.
Cited by
-
Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila.Aging (Albany NY). 2016 Nov 25;8(11):2988-3008. doi: 10.18632/aging.101107. Aging (Albany NY). 2016. PMID: 27889707 Free PMC article.
-
Sequence variants of BIEC2-808543 near LCORL are associated with body composition in Thoroughbreds under training.J Equine Sci. 2016;27(3):107-114. doi: 10.1294/jes.27.107. Epub 2016 Sep 30. J Equine Sci. 2016. PMID: 27703405 Free PMC article.
-
The Gene Score for Predicting Hypertriglyceridemia: New Insights from a Czech Case-Control Study.Mol Diagn Ther. 2019 Aug;23(4):555-562. doi: 10.1007/s40291-019-00412-2. Mol Diagn Ther. 2019. PMID: 31222479
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
