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Review
. 2016 Jan;25(1):22-7.
doi: 10.1097/MNH.0000000000000183.

Role of immune cells in salt-sensitive hypertension and renal injury

Brittany Wade  1 , Justine M Abais-Battad, David L Mattson
Affiliations
Review

Role of immune cells in salt-sensitive hypertension and renal injury

Brittany Wade et al. Curr Opin Nephrol Hypertens. 2016 Jan.

Abstract

Purpose of review: Immune mechanisms exacerbate the severity of hypertension in humans and animal models of disease. This review summarizes recent mechanistic studies exploring the pathways whereby immunity influences salt-sensitive hypertension and renal disease.

Recent findings: Emphasis is placed on the role of T cell subtypes, the mechanisms of T-cell activation, and the identification of potential antigens or neoantigens.

Summary: Significant advancements have occurred in the search for pathways which activate the adaptive immune response. An enhanced understanding of the factors contributing to hypertension can lead to better therapies.

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Conflict of interest statement

Conflicts of Interest

None

Figures

Figure 1
Figure 1
Proposed stimuli and mechanisms of action of immune cells in salt-sensitive hypertension.
See this image and copyright information in PMC

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