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Review
. 2016 Feb;41(1-2):222-30.
doi: 10.1007/s11064-015-1766-z. Epub 2015 Nov 16.

Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone

Yuki Hirota  1 , Masato Sawada  1 , Shih-Hui Huang  1 , Takashi Ogino  1 , Shinya Ohata  2 , Akiharu Kubo  3 , Kazunobu Sawamoto  4
Affiliations
Review

Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone

Yuki Hirota et al. Neurochem Res. 2016 Feb.

Abstract

In many animal species, the production of new neurons (neurogenesis) occurs throughout life, in a specialized germinal region called the ventricular-subventricular zone (V-SVZ). In this region, neural stem cells undergo self-renewal and generate neural progenitor cells and new neurons. In the olfactory system, the new neurons migrate rostrally toward the olfactory bulb, where they differentiate into mature interneurons. V-SVZ-derived new neurons can also migrate toward sites of brain injury, where they contribute to neural regeneration. Recent studies indicate that two major branches of the Wnt signaling pathway, the Wnt/β-catenin and Wnt/planar cell polarity pathways, play essential roles in various facets of adult neurogenesis. Here, we review the Wnt signaling-mediated regulation of adult neurogenesis in the V-SVZ under physiological and pathological conditions.

Keywords: Adult neurogenesis; Neural stem cells; Planar cell polarity; Regeneration; Ventricular–subventricular zone; Wnt signaling; β-Catenin.

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