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. 2014:2014:795371.
doi: 10.1155/2014/795371. Epub 2014 Jun 15.

Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study

Ashwin J Mali  1 , Atmaram P Pawar  1 , Ravindra N Purohit  1
Affiliations

Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study

Ashwin J Mali et al. J Pharm (Cairo). 2014.

Abstract

The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

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Figures

Figure 1
Figure 1
Response surface plots of (a) particle size, (b) entrapment efficiency, (c) bulk density, and (d) Carr's index.
Figure 2
Figure 2
Zeta potential of formulated DPI.
Figure 3
Figure 3
(a) TEM image and (b) SEM image of formulated DPI.
Figure 4
Figure 4
The FTIR of (a) budesonide, (b) formulated DPI, (c) chitosan, (d) sodium alginate, and (e) pluronic F-68.
Figure 5
Figure 5
(a) DSC plots and (b) PXRD plots of (A) budesonide, (B) formulated DPI, (C) chitosan, (D) sodium alginate, and (E) pluronic F-68.
Figure 6
Figure 6
In vitro drug release profile of formulated budesonide and commercial DPI. Data are presented as mean ± SD, n = 3.
Figure 7
Figure 7
Percentage cell viability against alveolar epithelial cancer cell line A549 of formulated budesonide and blank DPI and its excipients. Data are presented as mean ± SD, n = 3.
See this image and copyright information in PMC

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