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Review
. 2015 Dec;13(12):777-86.
doi: 10.1038/nrmicro3564. Epub 2015 Nov 9.

A century of the phage: past, present and future

George P C Salmond  1 , Peter C Fineran  2
Affiliations
Review

A century of the phage: past, present and future

George P C Salmond et al. Nat Rev Microbiol. 2015 Dec.

Abstract

Viruses that infect bacteria (bacteriophages; also known as phages) were discovered 100 years ago. Since then, phage research has transformed fundamental and translational biosciences. For example, phages were crucial in establishing the central dogma of molecular biology - information is sequentially passed from DNA to RNA to proteins - and they have been shown to have major roles in ecosystems, and help drive bacterial evolution and virulence. Furthermore, phage research has provided many techniques and reagents that underpin modern biology - from sequencing and genome engineering to the recent discovery and exploitation of CRISPR-Cas phage resistance systems. In this Timeline, we discuss a century of phage research and its impact on basic and applied biology.

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References

    1. Bacteriophage. 2011 Jan;1(1):31-45 - PubMed
    1. Expert Opin Drug Deliv. 2008 Mar;5(3):321-9 - PubMed
    1. Nature. 1989 Aug 10;340(6233):467-8 - PubMed
    1. MBio. 2014 Jul 01;5(4):e01379-14 - PubMed
    1. Bacteriophage. 2015 Jun 23;5(3):e1062590 - PubMed

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