Activation of HIV gene expression during monocyte differentiation by induction of NF-kappa B
- PMID: 2654643
- DOI: 10.1038/339070a0
Activation of HIV gene expression during monocyte differentiation by induction of NF-kappa B
Abstract
The latent period of AIDS is influenced by factors which activate human immunodeficiency virus (HIV) replication in different cell types. Although monocytic cells may provide a reservoir for virus production in vivo, their regulation of HIV transcription has not been defined. We now report that HIV gene expression in the monocyte lineage is regulated by NF-kappa B, the same transcription factor known to stimulate the HIV enhancer in activated T cells; however, control of NF-kappa B and HIV in monocytes differs from that observed in T cells. NF-kappa B-binding activity appears during the transition from promonocyte to monocyte in U937 cells induced to differentiate in vitro and is present constitutively in mature monocytes and macrophages. In a chronically infected promonocytic cell, U1, differentiation is associated with HIV-1 replication as well as NF-kappa B binding activity. These findings suggest that NF-kappa B binding activity is developmentally regulated in the monocyte lineage, and that it provides one signal for HIV activation in these cells.
Comment in
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NF-kB and HIV.Nature. 1990 Jan 18;343(6255):218-9. doi: 10.1038/343218b0. Nature. 1990. PMID: 2405277 No abstract available.
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