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. 2016 Jan;27(1):e5.
doi: 10.3802/jgo.2016.27.e5. Epub 2015 Dec 1.

Incidence of epithelial ovarian cancer according to histologic subtypes in Korea, 1999 to 2012

Se Ik Kim  1 , Myong Cheol Lim  2   3   4 , Jiwon Lim  5 , Young Joo Won  4   5 , Sang Soo Seo  2 , Sokbom Kang  2   3   4 , Sang Yoon Park  2   6
Affiliations

Incidence of epithelial ovarian cancer according to histologic subtypes in Korea, 1999 to 2012

Se Ik Kim et al. J Gynecol Oncol. 2016 Jan.

Abstract

Objective: To investigate trends in the incidence of epithelial ovarian cancer (EOC), according to histologic subtypes, in Korean women between 1999 and 2012.

Methods: Data from the Korea Central Cancer Registry recorded between 1999 and 2012 were evaluated. The incidences of EOC histologic subtypes were counted. Age-standardized incidence rates (ASRs) and annual percentage changes (APCs) in incidence rates were calculated. Patient data were divided into three groups based on age (<40, 40 to 59, and >59 years), and age-specific incidence rates were compared.

Results: Overall, the incidence of EOC has increased. Annual EOC cases increased from 922 in 1999 to 1,775 in 2012. In 1999, the ASR was 3.52 per 100,000 and increased to 4.79 per 100,000 in 2012 (APC, 2.53%; p<0.001). The ASRs in 2012 and APCs between 1999 and 2012 for the four major histologic subtypes were as follows (in order of incidence): serous carcinoma (ASR, 2.32 per 100,000; APC, 4.34%; p<0.001), mucinous carcinoma (ASR, 0.73 per 100,000; APC, -1.05%; p=0.131), endometrioid carcinoma (ASR, 0.51 per 100,000; APC, 1.48%; p=0.032), and clear cell carcinoma (ASR, 0.50 per 100,000; APC, 8.13%; p<0.001). In the sub-analyses based on age, clear cell carcinoma was confirmed as the histologic subtype whose incidence had increased the most since 1999.

Conclusion: The incidence of EOC is increasing in Korea. Among the histologic subtypes, the incidence of clear cell carcinoma has increased markedly across all age groups since 1999.

Keywords: Histologic Subtype; Incidence; Ovarian Neoplasms; Time Trends.

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Conflict of interest statement

Conflict of Interest: Myong Cheol Lim and Sokbom Kang serve as Editors for the Journal of Gynecologic Oncology, but have no role in the decision to publish this article. All remaining authors have declared no conflicts of interest.

Figures

Fig. 1
Fig. 1. Age-standardized incidence rates (ASRs) per 100,000 of epithelial ovarian cancer in Korea between 1999 and 2012.
Fig. 2
Fig. 2. Annual percent changes (APCs, %) of epithelial ovarian cancer according to age groups between 1999 and 2012.
Fig. 3
Fig. 3. Age-specific incidence rates of epithelial ovarian cancer for 2012 in Korea.
See this image and copyright information in PMC

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