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Review
. 2015:31:741-77.
doi: 10.1146/annurev-cellbio-100913-013020. Epub 2015 Sep 29.

Development of dendritic form and function

Julie L Lefebvre, Joshua R Sanes  1 , Jeremy N Kay  2
Affiliations
Review

Development of dendritic form and function

Julie L Lefebvre et al. Annu Rev Cell Dev Biol. 2015.

Abstract

The nervous system is populated by numerous types of neurons, each bearing a dendritic arbor with a characteristic morphology. These type-specific features influence many aspects of a neuron's function, including the number and identity of presynaptic inputs and how inputs are integrated to determine firing properties. Here, we review the mechanisms that regulate the construction of cell type-specific dendrite patterns during development. We focus on four aspects of dendrite patterning that are particularly important in determining the function of the mature neuron: (a) dendrite shape, including branching pattern and geometry of the arbor; (b) dendritic arbor size;

Keywords: dendrite; neural development; self-avoidance; synapse formation; tiling.

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