Fumonisins: oxidative stress-mediated toxicity and metabolism in vivo and in vitro

doi:10.1007/s00204-015-1604-8

Review

. 2016 Jan;90(1):81-101.

doi: 10.1007/s00204-015-1604-8. Epub 2015 Sep 29.

Fumonisins: oxidative stress-mediated toxicity and metabolism in vivo and in vitro

Xu Wang^{1

2}, Qinghua Wu^{3

4}, Dan Wan⁵, Qianying Liu⁵, Dongmei Chen⁵, Zhenli Liu⁶, María Rosa Martínez-Larrañaga², María Aránzazu Martínez², Arturo Anadón⁷, Zonghui Yuan^{8

9

10}

Affiliations

¹ National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.
² Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040, Madrid, Spain.
³ College of Life Science, Yangtze University, Jingzhou, China.
⁴ Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic.
⁵ MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.
⁶ Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan, Hubei, China.
⁷ Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040, Madrid, Spain. anadon@vet.ucm.es.
⁸ National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, 430070, Hubei, China. yuan5802@mail.hzau.edu.cn.
⁹ MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, 430070, Hubei, China. yuan5802@mail.hzau.edu.cn.
¹⁰ Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan, Hubei, China. yuan5802@mail.hzau.edu.cn.

PMID: 26419546
DOI: 10.1007/s00204-015-1604-8

Review

Fumonisins: oxidative stress-mediated toxicity and metabolism in vivo and in vitro

Xu Wang et al. Arch Toxicol. 2016 Jan.

. 2016 Jan;90(1):81-101.

doi: 10.1007/s00204-015-1604-8. Epub 2015 Sep 29.

Authors

Affiliations

¹ National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.
² Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040, Madrid, Spain.
³ College of Life Science, Yangtze University, Jingzhou, China.
⁴ Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic.
⁵ MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.
⁶ Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan, Hubei, China.
⁷ Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040, Madrid, Spain. anadon@vet.ucm.es.
⁸ National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, 430070, Hubei, China. yuan5802@mail.hzau.edu.cn.
⁹ MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, 430070, Hubei, China. yuan5802@mail.hzau.edu.cn.
¹⁰ Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan, Hubei, China. yuan5802@mail.hzau.edu.cn.

PMID: 26419546
DOI: 10.1007/s00204-015-1604-8

Abstract

Fumonisins (FBs) are widespread Fusarium toxins commonly found as corn contaminants. FBs could cause a variety of diseases in animals and humans, such as hepatotoxic, nephrotoxic, hepatocarcinogenic and cytotoxic effects in mammals. To date, almost no review has addressed the toxicity of FBs in relation to oxidative stress and their metabolism. The focus of this article is primarily intended to summarize the progress in research associated with oxidative stress as a plausible mechanism for FB-induced toxicity as well as the metabolism. The present review showed that studies have been carried out over the last three decades to elucidate the production of reactive oxygen species (ROS) and oxidative stress as a result of FBs treatment and have correlated them with various types of FBs toxicity, indicating that oxidative stress plays critical roles in the toxicity of FBs. The major metabolic pathways of FBs are hydrolysis, acylation and transamination. Ceramide synthase, carboxylesterase FumD and aminotransferase FumI could degrade FB1 and FB2. The cecal microbiota of pigs and alkaline processing such as nixtamalization can also transform FB1 into metabolites. Most of the metabolites of FB1 were less toxic than FB1, except its partial (pHFB1) metabolites. Further understanding of the role of oxidative stress in FB-induced toxicity will throw new light on the use of antioxidants, scavengers of ROS, as well as on the blind spots of metabolism and the metabolizing enzymes of FBs. The present review might contribute to reveal the toxicity of FBs and help to protect against their oxidative damage.

Keywords: Antioxidants; DNA damage; Fumonisins; Lipid peroxidation; Metabolism; Metabolizing enzymes; Oxidative stress; Reactive oxygen species.

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Fumonisins: oxidative stress-mediated toxicity and metabolism in vivo and in vitro

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Fumonisins: oxidative stress-mediated toxicity and metabolism in vivo and in vitro

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