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. 2015 Sep;7(9):613-5.
doi: 10.18632/aging.100813.

ARF: connecting senescence and innate immunity for clearance

Alper Y Kearney  1   2 , Benedict Anchang  3 , Sylvia Plevritis  3 , Dean W Felsher  1
Affiliations

ARF: connecting senescence and innate immunity for clearance

Alper Y Kearney et al. Aging (Albany NY). 2015 Sep.

Abstract

We have found evidence suggesting that ARF and p53 are essential for tumor regression upon MYC inactivation through distinct mechanisms ARF through p53-independent affect, is required to for MYC to regulate the expression of genes that are required for both the induction of cellular senescence as well as recruitment of innate immune activation. Our observations have possible implications for mechanisms of therapeutic resistance to targeted oncogene inactivation.

Keywords: Myc inactivation; innate immunity; p19arf; senescence.

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Conflict of interest statement

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1. ARF loss interferes with expression of genes associated with senescence and innate immune system
MYC inactivation, in the presence of ARF, triggers gene expression changes in pathways associated with senescence as well as macrophage and innate immune cell activation and infiltration. Microarray analysis revealed that ARF loss precludes these changes, which we propose may be how ARF loss blocks macrophage infiltration. SASP: Senescence-associated secretory phenotype.
See this image and copyright information in PMC

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