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Review
. 2015;5(3):453-69.
doi: 10.3233/JPD-150590.

Cognitive Impairment in Fall-Related Studies in Parkinson's Disease

Josefa M Domingos  1   2 , Catarina Godinho  2   3 , John Dean  4 , Miguel Coelho  2 , Anabela Pinto  5 , Bastiaan R Bloem  6 , Joaquim J Ferreira  1   2   7
Affiliations
Free PMC article
Review

Cognitive Impairment in Fall-Related Studies in Parkinson's Disease

Josefa M Domingos et al. J Parkinsons Dis. 2015.
Free PMC article

Abstract

Background: There is increasing evidence to suggest a tight relationship between cognitive impairment and falls in Parkinson's disease (PD). Here, we draw attention to a potentially significant flaw in the existent falls-related research, namely the apparent exclusion of patients with cognitive impairment or dementia.

Objective: Our objective was to review all published, on-going or scheduled fall-related intervention studies, in order to investigate the extent to which cognitively impaired individuals with PD were included in these studies.

Methods: We analyzed published controlled trials regarding falls and PD in commonly used databases, as well as relevant ongoing clinical trials registered within the World Health Organization database, clinicaltrials.gov and the European Clinical Trials Database.

Results: Fourteen of the fifteen published studies included had explicit cognitive exclusion criteria as part of their study protocol. Most of the 54 on-going PD fall-related studies excluded patients with cognitive impairment.

Conclusions: This suggests that individuals with cognitive impairment or dementia are excluded from fall-related research studies. We strongly recommend that future work in this area should include a representative sample of patients with PD, including subjects with cognitive decline.

Keywords: Falls; Parkinson disease; clinical trials; cognition; rehabilitation.

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References

    1. Litvan I, Aarsland D, Adler CH, Goldman JG, Kulisevsky J, Mollenhauer B, Rodriguez-Oroz MC, Troster AI, Weintraub D. MDS Task Force on mild cognitive impairment in Parkinson’s disease: Critical review of PD-MCI. Mov Disord. 2011;26:1814–1824. - PMC - PubMed
    1. Williams-Gray CH, Evans JR, Goris A, Foltynie T, Ban M, Robbins TW, Brayne C, Kolachana BS, Weinberger DR, Sawcer SJ, Barker RA. The distinct cognitive syndromes of Parkinson’s disease: 5 year follow-up of the CamPaIGN cohort. Brain. 2009;132:2958–2969. - PubMed
    1. Janvin CC, Larsen JP, Aarsland D, Hugdahl K. Subtypes of mild cognitive impairment in Parkinson’s disease: Progression to dementia. Mov Disord. 2006;21:1343–1349. - PubMed
    1. Asada T, Kariya T, Kinoshita T, Asaka A, Morikawa S, Yoshioka M, Kakuma T. Predictors of fall-relatedinjuries among community-dwelling elderly people with dementia. Age Ageing. 1996;25:22–28. - PubMed
    1. Clark RD, Lord SR, Webster IW. Clinical parameters associated with falls in an elderly population. Gerontology. 1993;39:117–123. - PubMed

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