Substrates of the human oligopeptide transporter hPEPT2
- PMID: 26355221
- DOI: 10.5582/bst.2015.01078
Substrates of the human oligopeptide transporter hPEPT2
Abstract
Oligopeptide transporters serve important functions in nutrition and pharmacology. In particular, these transporters help maintain the homeostasis of peptides. The peptide-transporter PEPT2 is a high-affinity and low-capacity type oligopeptide transporter from the proton-coupled oligopeptide transporter family. PEPT2 has recently received attention because of its potential application in targeted drug delivery. PEPT2 is widely distributed in kidney, central nervous system, and lung of organisms. In general, all dipeptides, tripeptides, and peptide-like drugs such as β-lactam antibiotics and angiotensin-converting enzyme inhibitors could be mediated and transported as a substrate of PEPT2. The design of many extant drugs and prodrugs is based on the substrate structure of PEPT2 to accelerate absorption via peptide transporters. Thus, this paper summarizes the substrate features of PEPT2 to promote the rational design of drugs and prodrugs that target peptide transporters.
Similar articles
-
Biology of Peptide Transporter 2 in Mammals: New Insights into Its Function, Structure and Regulation.Cells. 2022 Sep 14;11(18):2874. doi: 10.3390/cells11182874. Cells. 2022. PMID: 36139448 Free PMC article. Review.
-
Functional characterization of brain peptide transporter in rat cerebral cortex: identification of the high-affinity type H+/peptide transporter PEPT2.Brain Res. 2004 Jan 30;997(1):52-61. doi: 10.1016/j.brainres.2003.10.049. Brain Res. 2004. PMID: 14715149
-
Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions.Curr Drug Targets. 2003 Jul;4(5):373-88. doi: 10.2174/1389450033491028. Curr Drug Targets. 2003. PMID: 12816347 Review.
-
Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls.Expert Opin Drug Metab Toxicol. 2009 Aug;5(8):887-905. doi: 10.1517/17425250903042292. Expert Opin Drug Metab Toxicol. 2009. PMID: 19519280 Review.
-
Structural requirements for determining the substrate affinity of peptide transporters PEPT1 and PEPT2.Pflugers Arch. 2000 Sep;440(5):679-84. doi: 10.1007/s004240000339. Pflugers Arch. 2000. PMID: 11007306
Cited by
-
Critical Roles of the Cysteine-Glutathione Axis in the Production of γ-Glutamyl Peptides in the Nervous System.Int J Mol Sci. 2023 Apr 28;24(9):8044. doi: 10.3390/ijms24098044. Int J Mol Sci. 2023. PMID: 37175751 Free PMC article. Review.
-
Transporter-Mediated Drug Delivery.Molecules. 2023 Jan 24;28(3):1151. doi: 10.3390/molecules28031151. Molecules. 2023. PMID: 36770817 Free PMC article. Review.
-
Biology of Peptide Transporter 2 in Mammals: New Insights into Its Function, Structure and Regulation.Cells. 2022 Sep 14;11(18):2874. doi: 10.3390/cells11182874. Cells. 2022. PMID: 36139448 Free PMC article. Review.
-
The ubiquitin ligase Nedd4-2 mediates the regulation of PepT2 by mTORC1 in bovine mammary epithelial cells.Anim Nutr. 2022 Feb 10;10:12-18. doi: 10.1016/j.aninu.2021.11.008. eCollection 2022 Sep. Anim Nutr. 2022. PMID: 35601254 Free PMC article.
-
Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters.J Physiol. 2022 May;600(10):2377-2400. doi: 10.1113/JP282781. Epub 2022 Apr 28. J Physiol. 2022. PMID: 35413133 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
