Embryonic stages in cerebellar afferent development

doi:10.1186/s40673-015-0026-y

Review

. 2015 Jun 11:2:7.

doi: 10.1186/s40673-015-0026-y. eCollection 2015.

Embryonic stages in cerebellar afferent development

Maryam Rahimi-Balaei¹, Pegah Afsharinezhad², Karen Bailey², Matthew Buchok², Behzad Yeganeh³, Hassan Marzban¹

Affiliations

¹ Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences, University of Manitoba, Rm129, BMSB, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9 Canada ; College of Medicine, Faculty of Health Sciences, Manitoba Institute of Child Health (MICH), University of Manitoba, Winnipeg, Manitoba Canada.
² Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences, University of Manitoba, Rm129, BMSB, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9 Canada.
³ Program in Physiology and Experimental Medicine, Hospital for Sick Children and University of Toronto, Toronto, Ontario Canada.

PMID: 26331050
PMCID: PMC4552263
DOI: 10.1186/s40673-015-0026-y

Review

Embryonic stages in cerebellar afferent development

Maryam Rahimi-Balaei et al. Cerebellum Ataxias. 2015.

. 2015 Jun 11:2:7.

doi: 10.1186/s40673-015-0026-y. eCollection 2015.

Authors

Maryam Rahimi-Balaei¹, Pegah Afsharinezhad², Karen Bailey², Matthew Buchok², Behzad Yeganeh³, Hassan Marzban¹

Affiliations

¹ Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences, University of Manitoba, Rm129, BMSB, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9 Canada ; College of Medicine, Faculty of Health Sciences, Manitoba Institute of Child Health (MICH), University of Manitoba, Winnipeg, Manitoba Canada.
² Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences, University of Manitoba, Rm129, BMSB, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9 Canada.
³ Program in Physiology and Experimental Medicine, Hospital for Sick Children and University of Toronto, Toronto, Ontario Canada.

PMID: 26331050
PMCID: PMC4552263
DOI: 10.1186/s40673-015-0026-y

Abstract

The cerebellum is important for motor control, cognition, and language processing. Afferent and efferent fibers are major components of cerebellar circuitry and impairment of these circuits causes severe cerebellar malfunction, such as ataxia. The cerebellum receives information from two major afferent types - climbing fibers and mossy fibers. In addition, a third set of afferents project to the cerebellum as neuromodulatory fibers. The spatiotemporal pattern of early cerebellar afferents that enter the developing embryonic cerebellum is not fully understood. In this review, we will discuss the cerebellar architecture and connectivity specifically related to afferents during development in different species. We will also consider the order of afferent fiber arrival into the developing cerebellum to establish neural connectivity.

Keywords: Cerebellar primordium; Climbing fiber; Mossy fiber; Neuromodulatory fiber.

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References

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[1] Ito M. The modifiable neuronal network of the cerebellum. Jpn J Physiol. 1984;34:781–92. - PubMed

[2] Ito M. The modifiable neuronal network of the cerebellum. Jpn J Physiol. 1984;34:781–92. - PubMed

[3] Ito M. Control of mental activities by internal models in the cerebellum. Nat Rev Neurosci. 2008;9:304–13. - PubMed

[4] Ito M. Control of mental activities by internal models in the cerebellum. Nat Rev Neurosci. 2008;9:304–13. - PubMed

[5] Leiner HC, Leiner AL, Dow RS. Does the cerebellum contribute to mental skills? Behav Neurosci. 1986;100:443–54. - PubMed

[6] Leiner HC, Leiner AL, Dow RS. Does the cerebellum contribute to mental skills? Behav Neurosci. 1986;100:443–54. - PubMed

[7] Schmahmann JD. From movement to thought: anatomic substrates of the cerebellar contribution to cognitive processing. Hum Brain Mapp. 1996;4:174–98. - PubMed

[8] Schmahmann JD. From movement to thought: anatomic substrates of the cerebellar contribution to cognitive processing. Hum Brain Mapp. 1996;4:174–98. - PubMed

[9] Reeber SL, Otis TS, Sillitoe RV. New roles for the cerebellum in health and disease. Front Syst Neurosci. 2013;7:83. - PMC - PubMed

[10] Reeber SL, Otis TS, Sillitoe RV. New roles for the cerebellum in health and disease. Front Syst Neurosci. 2013;7:83. - PMC - PubMed

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Embryonic stages in cerebellar afferent development

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Embryonic stages in cerebellar afferent development

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