Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Aug 21;16(8):19886-919.
doi: 10.3390/ijms160819886.

Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Jun Wang  1 , Yong-Xi Song  2 , Bin Ma  3 , Jia-Jun Wang  1 , Jing-Xu Sun  4 , Xiao-Wan Chen  5 , Jun-Hua Zhao  6 , Yu-Chong Yang  7 , Zhen-Ning Wang  8
Affiliations
Review

Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Jun Wang et al. Int J Mol Sci. .

Abstract

Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

Keywords: biomarkers; colorectal cancer; dysregulation; non-coding RNAs; targets.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Five categories of lncRNAs. According to the position in the genome, they can generally be classified into the following categories: intergenic, intronic, bidirectional, sense, and antisense lncRNAs.
Figure 2
Figure 2
Representative oncogenic miRNAs and their target genes in CRC.
Figure 3
Figure 3
Representative tumor suppressor miRNAs and their target genes in CRC.
Figure 4
Figure 4
The biological mechanisms of MALAT1 in CRC. Resveratrol could suppress CRC cell invasion and migration by inhibiting Wnt/β-catenin signaling pathway through downregulating MALAT1; MALAT1 might promote CRC development via targeting AKAP-9; MALAT1 could bind to SFPQ and release PTBP2 from the SFPQ/PTBP2 complex that promotes tumor growth and migration.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. International Human Genome Sequencing Consortium Finishing the euchromatic sequence of the human genome. Nature. 2004;431:931–945. - PubMed
    1. Palazzo A.F., Lee E.S. Non-coding RNA: What is functional and what is junk? Front. Genet. 2015;6 doi: 10.3389/fgene.2015.00002. - DOI - PMC - PubMed
    1. Kaikkonen M.U., Lam M.T., Glass C.K. Non-coding RNAs as regulators of gene expression and epigenetics. Cardiovasc. Res. 2011;90:430–440. doi: 10.1093/cvr/cvr097. - DOI - PMC - PubMed
    1. Li M., Izpisua Belmonte J.C. Roles for noncoding RNAs in cell-fate determination and regeneration. Nat. Struct. Mol. Boil. 2015;22:2–4. doi: 10.1038/nsmb.2946. - DOI - PubMed
    1. Piccoli M.T., Gupta S.K., Thum T. Noncoding RNAs as regulators of cardiomyocyte proliferation and death. J. Mol. Cell. Cardiol. 2015 doi: 10.1016/j.yjmcc.2015.02.002. - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources