Epstein-Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma

doi:10.1007/s12094-015-1354-3

. 2016 Feb;18(2):206-11.

doi: 10.1007/s12094-015-1354-3. Epub 2015 Aug 11.

Epstein-Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma

Z Zeng^{1

2

3}, S Fan⁴, X Zhang⁵, S Li⁵, M Zhou^{1

2

3}, W Xiong^{1

2

3}, M Tan^{2

6}, W Zhang^{7

8

9}, G Li^{10

11

12}

Affiliations

¹ Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.
² Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
⁴ Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
⁵ Department of Medical Laboratory Science, Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.
⁶ Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.
⁷ Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China. zhangwenling73@126.com.
⁸ Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China. zhangwenling73@126.com.
⁹ Department of Medical Laboratory Science, Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China. zhangwenling73@126.com.
¹⁰ Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China. lgy@csu.edu.cn.
¹¹ Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China. lgy@csu.edu.cn.
¹² Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. lgy@csu.edu.cn.

PMID: 26260913
DOI: 10.1007/s12094-015-1354-3

Epstein-Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma

Z Zeng et al. Clin Transl Oncol. 2016 Feb.

. 2016 Feb;18(2):206-11.

doi: 10.1007/s12094-015-1354-3. Epub 2015 Aug 11.

Authors

Z Zeng^{1

2

3}, S Fan⁴, X Zhang⁵, S Li⁵, M Zhou^{1

2

3}, W Xiong^{1

2

3}, M Tan^{2

6}, W Zhang^{7

8

9}, G Li^{10

11

12}

Affiliations

¹ Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.
² Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
⁴ Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
⁵ Department of Medical Laboratory Science, Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.
⁶ Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.
⁷ Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China. zhangwenling73@126.com.
⁸ Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China. zhangwenling73@126.com.
⁹ Department of Medical Laboratory Science, Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China. zhangwenling73@126.com.
¹⁰ Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China. lgy@csu.edu.cn.
¹¹ Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China. lgy@csu.edu.cn.
¹² Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. lgy@csu.edu.cn.

PMID: 26260913
DOI: 10.1007/s12094-015-1354-3

Abstract

Purpose: EBER-1 (a non-coding RNA transcribed by EBV) expression was detected in most of Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) patients. However, the relevance between EBER-1 expression and NPC clinical outcome has not been reported. This study aims to assess the possible correlations of EBER-1 expression and clinical parameters and its potential prognostic predictive ability in NPC patient's outcomes.

Methods: We examined EBER-1 mRNA expression in 301 NPC and 130 non-NPC tissues using in situ hybridization and did statistics.

Results: EBER-1 expression was up-regulated in NPC tissues when compared to non-NPC tissues. A receiver operating characteristic analysis revealed that EBER-1 expression could distinguish non-cancerous patients from NPC patients (p < 0.001, sensitivity: 72.5 %, specificity: 83.5 %, AUC = 0.815). A survival analysis revealed that patients with high levels of EBER-1 expression had a significantly good prognosis (Disease-free survival: p = 0.019, overall survival: p = 0.006).

Conclusion: These results indicated that EBER-1 expression is a potential prognosis factor of NPC and highly negative correlated with the progress of NPC.

Keywords: EBV-encoded small RNA 1 (EBER-1); Epstein–Barr virus (EBV); Nasopharyngeal carcinoma (NPC); Prognosis.

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References

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[1] Int J Cancer. 2008 Nov 1;123(9):2065-72 - PubMed

[2] Int J Cancer. 2008 Nov 1;123(9):2065-72 - PubMed

[3] Hum Pathol. 2006 May;37(5):593-605 - PubMed

[4] Hum Pathol. 2006 May;37(5):593-605 - PubMed

[5] EMBO J. 1996 Jun 3;15(11):2748-59 - PubMed

[6] EMBO J. 1996 Jun 3;15(11):2748-59 - PubMed

[7] Semin Cancer Biol. 2012 Apr;22(2):162-5 - PubMed

[8] Semin Cancer Biol. 2012 Apr;22(2):162-5 - PubMed

[9] J Cancer Res Clin Oncol. 2007 Feb;133(2):71-81 - PubMed

[10] J Cancer Res Clin Oncol. 2007 Feb;133(2):71-81 - PubMed

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Epstein-Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma

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Epstein-Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma

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