Molecular network of neuronal autophagy in the pathophysiology and treatment of depression

doi:10.1007/s12264-015-1548-2

. 2015 Aug;31(4):427-34.

doi: 10.1007/s12264-015-1548-2. Epub 2015 Aug 8.

Molecular network of neuronal autophagy in the pathophysiology and treatment of depression

Jack Jia¹, Weidong Le

Affiliations

Affiliation

¹ Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA.

PMID: 26254058
PMCID: PMC5563719
DOI: 10.1007/s12264-015-1548-2

Molecular network of neuronal autophagy in the pathophysiology and treatment of depression

Jack Jia et al. Neurosci Bull. 2015 Aug.

. 2015 Aug;31(4):427-34.

doi: 10.1007/s12264-015-1548-2. Epub 2015 Aug 8.

Authors

Jack Jia¹, Weidong Le

Affiliation

¹ Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA.

PMID: 26254058
PMCID: PMC5563719
DOI: 10.1007/s12264-015-1548-2

Abstract

Major depressive disorder (MDD) is a complicated multifactorial induced disease, characterized by depressed mood, anhedonia, fatigue, and altered cognitive function. Recently, many studies have shown that antidepressants regulate autophagy. In fact, autophagy, a conserved lysosomal degradation pathway, is essential for the central nervous system. Dysregulation of autophagic pathways, such as the mammalian target of rapamycin (mTOR) signaling pathway and the beclin pathway, has been studied in neurodegenerative diseases. However, autophagy in MDD has not been fully studied. Here, we discuss whether the dysregulation of autophagy contributes to the pathophysiology and treatment of MDD and summarize the current evidence that shows the involvement of autophagy in MDD.

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References

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[1] Eshel N, Roiser JP. Reward and punishment processing in depression. Biol Psychiatry. 2010;68:118–124. doi: 10.1016/j.biopsych.2010.01.027. - DOI - PubMed

[2] Eshel N, Roiser JP. Reward and punishment processing in depression. Biol Psychiatry. 2010;68:118–124. doi: 10.1016/j.biopsych.2010.01.027. - DOI - PubMed

[3] Ito M. Long-term depression. Annu Rev Neurosci. 1989;12:85–102. doi: 10.1146/annurev.ne.12.030189.000505. - DOI - PubMed

[4] Ito M. Long-term depression. Annu Rev Neurosci. 1989;12:85–102. doi: 10.1146/annurev.ne.12.030189.000505. - DOI - PubMed

[5] Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSMIV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:617–627. doi: 10.1001/archpsyc.62.6.617. - DOI - PMC - PubMed

[6] Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSMIV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:617–627. doi: 10.1001/archpsyc.62.6.617. - DOI - PMC - PubMed

[7] Wang PS, Simon G, Kessler RC. The economic burden of depression and the cost-effectiveness of treatment. Int J Methods Psychiatr Res. 2003;12:22–33. doi: 10.1002/mpr.139. - DOI - PMC - PubMed

[8] Wang PS, Simon G, Kessler RC. The economic burden of depression and the cost-effectiveness of treatment. Int J Methods Psychiatr Res. 2003;12:22–33. doi: 10.1002/mpr.139. - DOI - PMC - PubMed

[9] Nierenberg AA, Ostacher MJ, Huffman JC, Ametrano RM, Fava M, Perlis RH. A brief review of antidepressant effi cacy, effectiveness, indications, and usage for major depressive disorder. J Occup Environ Med. 2008;50:428–436. doi: 10.1097/JOM.0b013e31816b5034. - DOI - PubMed

[10] Nierenberg AA, Ostacher MJ, Huffman JC, Ametrano RM, Fava M, Perlis RH. A brief review of antidepressant effi cacy, effectiveness, indications, and usage for major depressive disorder. J Occup Environ Med. 2008;50:428–436. doi: 10.1097/JOM.0b013e31816b5034. - DOI - PubMed

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Molecular network of neuronal autophagy in the pathophysiology and treatment of depression

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Molecular network of neuronal autophagy in the pathophysiology and treatment of depression

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