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. 2015 Jul 26;7(6):894-8.
doi: 10.4252/wjsc.v7.i6.894.

Enhancing endothelial progenitor cell for clinical use

Lei Ye  1 , Kian-Keong Poh  1
Affiliations

Enhancing endothelial progenitor cell for clinical use

Lei Ye et al. World J Stem Cells. .

Abstract

Circulating endothelial progenitor cells (EPCs) have been demonstrated to correlate negatively with vascular endothelial dysfunction and cardiovascular risk factors. However, translation of basic research into the clinical practice has been limited by the lack of unambiguous and consistent definitions of EPCs and reduced EPC cell number and function in subjects requiring them for clinical use. This article critically reviews the definition of EPCs based on commonly used protocols, their value as a biomarker of cardiovascular risk factor in subjects with cardiovascular disease, and strategies to enhance EPCs for treatment of ischemic diseases.

Keywords: CD34; Cell therapy; Clinical trials; Endothelial progenitor cells; Enhancing function and number.

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