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Review
. 2014 Dec 12;3(4):1402-36.
doi: 10.3390/jcm3041402.

Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead

Kristine Freude  1 , Carlota Pires  2 , Poul Hyttel  3 , Vanessa Jane Hall  4
Affiliations
Review

Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead

Kristine Freude et al. J Clin Med. .

Abstract

The future hope of generated induced pluripotent stem cells (iPS cells) from Alzheimer's disease patients is multifold. Firstly, they may help to uncover novel mechanisms of the disease, which could lead to the development of new and unprecedented drugs for patients and secondly, they could also be directly used for screening and testing of potential new compounds for drug discovery. In addition, in the case of familial known mutations, these cells could be targeted by use of advanced gene-editing techniques to correct the mutation and be used for future cell transplantation therapies. This review summarizes the work so far in regards to production and characterization of iPS cell lines from both sporadic and familial Alzheimer's patients and from other iPS cell lines that may help to model the disease. It provides a detailed comparison between published reports and states the present hurdles we face with this new technology. The promise of new gene-editing techniques and accelerated aging models also aim to move this field further by providing better control cell lines for comparisons and potentially better phenotypes, respectively.

Keywords: Alzheimer’s disease; disease modeling; human; induced pluripotent stem cells.

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Figures

Figure 1
Figure 1
Schematic illustration of the use of induced pluripotent stem (iPS) cells in relation to Alzheimer’s disease (AD). (A) iPS cells are derived from a skin biopsy from an AD patient and differentiated into neural progenitor cells and neurons; (B) In familial cases, the disease-causing mutation can be corrected by gene-editing of the iPS cells, and neural progenitor cells and neurons can be used for research and drug screening; (C) The patients can in the long run benefit from these activities by cell therapy, better diagnostic procedures, customized treatments and novel medical approaches.
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