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Review
. 2015 Aug;29(4):609-17.
doi: 10.1016/j.hoc.2015.04.010. Epub 2015 Jun 11.

Mouse Models of Pancreatic Ductal Adenocarcinoma

Mariano Ponz-Sarvise  1 , David A Tuveson  2 , Kenneth H Yu  3
Affiliations
Review

Mouse Models of Pancreatic Ductal Adenocarcinoma

Mariano Ponz-Sarvise et al. Hematol Oncol Clin North Am. 2015 Aug.

Abstract

Only 10% to 15% of patients with pancreatic ductal adenocarcinoma (PDAC) are candidates for potentially curative surgery due to the location or spread of disease at the time of diagnosis. Despite rapid progress in the understanding of the molecular mechanisms underlying PDAC, translation to effective therapies has been modest at best. One of the key tools available for studying biology and developing more effective therapeutics is the laboratory mouse, mus musculus. This article explores new and innovative approaches to mouse modeling and how these approaches can be utilized to move the field forward.

Keywords: Genetic engineered mouse models; Kras; Models of cancer; Pancreatic cancer; Therapeutics.

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