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. 2015 Jun;4(6):324-37.
doi: 10.1002/psp4.41. Epub 2015 Jun 15.

A Tutorial on Target-Mediated Drug Disposition (TMDD) Models

P Dua  1 , E Hawkins  2 , P H van der Graaf  3
Affiliations

A Tutorial on Target-Mediated Drug Disposition (TMDD) Models

P Dua et al. CPT Pharmacometrics Syst Pharmacol. 2015 Jun.

Abstract

Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 code for some models discussed in this Tutorial are provided in the Supplementary Materials.

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Figures

Figure 1
Figure 1
Flow chart showing the development of TMDD models. References alongside arrows indicate who developed the model (example models are provided in Berkeley Madonna code in the Supplementary Material).
Figure 2
Figure 2
One-compartment TMDD model.
Figure 3
Figure 3
Two-compartment TMDD model, with binding in the central compartment.
Figure 4
Figure 4
Model with two drugs binding to the same target.
Figure 5
Figure 5
Two-compartment TMDD model with binding in both tissue and central compartments.
Figure 6
Figure 6
Flow chart showing the mathematical investigations completed on TMDD models in the current literature.
See this image and copyright information in PMC

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References

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