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. 1989 Dec 15;264(3):925-8.
doi: 10.1042/bj2640925.

Translational regulation of ferritin synthesis in rat liver. Effects of chronic dietary iron overload

G Cairo  1 , L Tacchini, L Schiaffonati, E Rappocciolo, E Ventura, A Pietrangelo
Affiliations

Translational regulation of ferritin synthesis in rat liver. Effects of chronic dietary iron overload

G Cairo et al. Biochem J. .

Abstract

In rats with chronic dietary iron overload, a higher amount of liver ferritin L-subunit mRNA was found mainly engaged on polysomes, whereas in control rats ferritin L-subunit mRNA molecules were largely stored in ribonucleoprotein particles. On the other hand, ferritin H-subunit mRNA was unchanged by chronic iron load and remained in the inactive cytoplasmic pool. In agreement with previous reports, in rats acutely treated with parenteral iron, only the ferritin L-subunit mRNA increased in amount, whereas both ferritin subunit mRNAs shifted to polysomes. This may indicate that, whereas in acute iron overload the hepatocyte operates a translation shift of both ferritin mRNAs to confront rapidly the abrupt entry of iron into the cell, during chronic iron overload it responds to the slow iron influx by translating a greater amount of L-subunit mRNA to synthesize isoferritins more suitable for long-term iron storage.

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References

    1. Biochem Biophys Res Commun. 1989 Apr 28;160(2):453-9 - PubMed
    1. Gene. 1988 Dec 10;72(1-2):201-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Mar;73(3):857-61 - PubMed
    1. Biochem J. 1978 Sep 1;173(3):969-77 - PubMed
    1. J Biol Chem. 1980 Jun 10;255(11):5195-200 - PubMed

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