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. 2015 Oct;34(10):1131-2.
doi: 10.1097/INF.0000000000000825.

Viral Load in Infants Hospitalized for Respiratory Syncytial Virus Bronchiolitis Correlates with Recurrent Wheezing at Thirty-Six-Month Follow-Up

Raffaella Nenna  1 , Marianna Ferrara, Ambra Nicolai, Alessandra Pierangeli, Carolina Scagnolari, Paola Papoff, Guido Antonelli, Corrado Moretti, Fabio Midulla
Affiliations

Viral Load in Infants Hospitalized for Respiratory Syncytial Virus Bronchiolitis Correlates with Recurrent Wheezing at Thirty-Six-Month Follow-Up

Raffaella Nenna et al. Pediatr Infect Dis J. 2015 Oct.

Abstract

The relationship between viral infection, host immune response in infants with respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing is discussed. We measured RSV-RNA load and interferon-λ1-3 expression in the nasopharyngeal washings from 68 infants hospitalized for RSV bronchiolitis, and wheezing was assessed 36 months after the first episode of bronchiolitis. Higher RSV-RNA load and higher interferon-λ2/3 levels were found in children with recurrent wheezing at 36-month follow-up.

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