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. 2015 Nov;26(11):1814-9.
doi: 10.1007/s13361-015-1201-3. Epub 2015 Jun 30.

The SEQUEST family tree

David L Tabb  1
Affiliations

The SEQUEST family tree

David L Tabb. J Am Soc Mass Spectrom. 2015 Nov.

Abstract

Since its introduction in 1994, SEQUEST has gained many important new capabilities, and a host of successor algorithms have built upon its successes. This Account and Perspective maps the evolution of this important tool and charts the relationships among contributions to the SEQUEST legacy. Many of the changes represented improvements in computing speed by clusters and graphics cards. Mass spectrometry innovations in mass accuracy and activation methods led to shifts in fragment modeling and scoring strategies. These changes, as well as the movement of laboratories and lab members, have led to great diversity among the members of the SEQUEST family. Graphical Abstract ᅟ.

Keywords: Bioinformatics; History; Intellectual property; Proteomics; SEQUEST.

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Figures

Figure 1
Figure 1
A tree representing the descendants of the original SEQUEST algorithm. Blue algorithms were produced in the Yates Laboratory, while yellow were produced in conjunction with commercial partners Thermo Fisher Scientific or Sage-N Research. Orange represents developments in the Noble Laboratory, with green denoting developments in the Gerber Laboratory and purple marking advances from Jimmy Eng after the year 2000. An arrow does not imply direct use of source code.
See this image and copyright information in PMC

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