Keap1-Nrf2 signalling in pancreatic cancer
- PMID: 26117456
- DOI: 10.1016/j.biocel.2015.06.017
Keap1-Nrf2 signalling in pancreatic cancer
Abstract
Transcription factor NF-E2 p45-related factor 2 (Nrf2, also called Nfe2l2), a master regulator of redox homeostasis, and its dominant negative regulator, Kelch-like ECH-associated protein 1 (Keap1), together tightly control the expression of numerous detoxifying and antioxidant genes. Nrf2 and the 'antioxidant response element' (ARE)-driven genes it controls are frequently upregulated in pancreatic cancer and correlate with poor survival. Upregulation of Nrf2 is, at least in part, K-Ras oncogene-driven and contributes to pancreatic cancer proliferation and chemoresistance. In this review, we aim to provide an overview of Keap1-Nrf2 signalling as it relates to pancreatic cancer, discussing the effects of inhibiting Nrf2 or Nrf2/ARE effector proteins to increase chemosensitivity.
Keywords: AKR1B10; Keap1; NQO1; Nrf2; Pancreatic cancer.
Copyright © 2015 Elsevier Ltd. All rights reserved.
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